Hepsin promotes prostate cancer progression and metastasis

被引：215

作者：

Klezovitch, O

Chevillet, J

Mirosevich, J

Roberts, RL

Matusik, RJ

Vasioukhin, V ^{[1
]}

机构：

[1] Fred Hutchinson Canc Res Ctr, Div Human Biol, Seattle, WA 98109 USA

[2] Univ Washington, Mol & Cellular Biol Program, Seattle, WA 98195 USA

[3] Vanderbilt Univ, Med Ctr, Dept Urol Surg, Vanderbilt Prostate Canc Ctr, Nashville, TN 37232 USA

[4] Vanderbilt Univ, Med Ctr, Dept Canc Biol, Vanderbilt Ingram Canc Ctr, Nashville, TN 37232 USA

来源：

CANCER CELL | 2004年 / 6卷 / 02期

关键词：

D O I：

10.1016/j.ccr.2004.07.008

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The majority of cancer-related deaths are associated with metastasis; however, little is known about the mechanisms of this process. Hepsin is a cell surface serine protease that is markedly upregulated in human prostate cancer; however, the functional significance of this upregulation is unknown. We report here that hepsin overexpression in prostate epithelium in vivo causes disorganization of the basement membrane. Overexpression of hepsin in a mouse model of nonmetastasizing prostate cancer has no impact on cell proliferation, but causes disorganization of the basement membrane and promotes primary prostate cancer progression and metastasis to liver, lung, and bone. We provide in vivo evidence that upregulation of a cell surface serine protease in a primary tumor promotes cancer progression and metastasis.

引用

页码：185 / 195

页数：11

共 40 条

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