Neomastoidin A, a Novel Monoacylglycerol with an Amino Acid Moiety from Macrolepiota neomastoidea

被引：5

作者：

Kim, Ki Hyun ^{[1
]}

Choi, Sang Un ^{[2
]}

Lee, Kang Ro ^{[1
]}

机构：

[1] Sungkyunkwan Univ, Coll Pharm, Nat Prod Lab, Suwon 440746, South Korea

[2] Korea Res Inst Chem Technol, Teajeon 305600, South Korea

来源：

CHEMISTRY LETTERS | 2009年 / 38卷 / 09期

关键词：

CHLOROPHYLLUM-MOLYBDITES; ALKALOIDS;

D O I：

10.1246/cl.2009.894

中图分类号：

O6 [化学];

学科分类号：

070301 [无机化学];

摘要：

A novel monoacylglycerol with an amino acid moiety, neomastoidin A (1), was isolated from the fruiting bodies of the poisonous mushroom Macrolepiota neomastoidea. The structure of 1 was established by extensive spectroscopic analysis and further confirmed by application of a dibenzoate chirality method. Neomastoidin A (1) exhibited cytotoxicity against SK-OV-3 and SK-MEL-2 cell lines.

引用

收藏

页码：894 / 895

页数：2

相关论文

共 12 条

[1]

Synthesis and anticonvulsant activities of (R)-(O)-methylserine derivatives [J].

Andurkar, SV ;

Stables, JP ;

Kohn, H .

TETRAHEDRON-ASYMMETRY, 1998, 9 (21) :3841-3854

[2]

Monoglycerides from the brown alga Sargassum sagamianum:: Isolation, synthesis, and biological activity [J].

Chang, Hyeun Wook ;

Jang, Kyoung Hwa ;

Lee, Doohyun ;

Kang, Hee Ryong ;

Kim, Tae-Yoon ;

Lee, Bong Ho ;

Choi, Byoung Wook ;

Kim, Sanghee ;

Shin, Jongheon .

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2008, 18 (12) :3589-3592

[3]

HIGUCHI R, 1994, LIEBIGS ANN CHEM, P653

[4]

Aldehyde dehydrogenase inhibitors from the mushroom Clitocybe clavipes [J].

Kawagishi, H ;

Miyazawa, T ;

Kume, H ;

Arimoto, Y ;

Inakuma, T .

JOURNAL OF NATURAL PRODUCTS, 2002, 65 (11) :1712-1714

[5]

Kim KH, 2008, B KOREAN CHEM SOC, V29, P1591

[6]

Macrolepiotin, a new indole alkaloid from Macrolepiota neomastoidea [J].

Kim, Ki Hyun ;

Park, Ki Moon ;

Choi, Sang Un ;

Lee, Kang Ro .

JOURNAL OF ANTIBIOTICS, 2009, 62 (06) :335-338

[7]

MUSHROOM POISONING BY CHLOROPHYLLUM-MOLYBDITES IN THE MIDWEST UNITED-STATES - CASES AND A REVIEW OF THE SYNDROME [J].

LEHMANN, PF ;

KHAZAN, U .

MYCOPATHOLOGIA, 1992, 118 (01) :3-13

[8]

Bacterial preparation of enantiopure unactivated aziridine-2-carboxamides and their transformation into enantiopure nonnatural amino acids and vic-diamines [J].

Moran-Ramallal, Roberto ;

Liz, Ramon ;

Gotor, Vicente .

ORGANIC LETTERS, 2007, 9 (03) :521-524

[9]

Lepiotins A and B, new alkaloids from the mushrooms, Macrolepiota neomastoidea and Chlorophyllum molybdites [J].

Ohta, T ;

Inoue, H ;

Kusano, G ;

Oshima, Y .

HETEROCYCLES, 1998, 47 (02) :883-891

[10]

NEW COLORIMETRIC CYTOTOXICITY ASSAY FOR ANTICANCER-DRUG SCREENING [J].

SKEHAN, P ;

STORENG, R ;

SCUDIERO, D ;

MONKS, A ;

MCMAHON, J ;

VISTICA, D ;

WARREN, JT ;

BOKESCH, H ;

KENNEY, S ;

BOYD, MR .

JOURNAL OF THE NATIONAL CANCER INSTITUTE, 1990, 82 (13) :1107-1112