Chemotherapy-related and late occurring - Philadelphia chromosome in AML, ALL and CML. Similar events related to treatment with DNA topoisomerase II inhibitors?

被引:56
作者
PedersenBjergaard, J
BrondumNielsen, K
Karle, H
Johansson, B
机构
[1] JOHN F KENNEDY INST,DEPT MED GENET,DK-2600 GLOSTRUP,DENMARK
[2] HERLEV SYGEHUS,DEPT HEMATOL,HERLEV,DENMARK
[3] UNIV LUND HOSP,DEPT CLIN GENET,S-22185 LUND,SWEDEN
关键词
Philadelphia chromosome; therapy-related leukemia; secondary leukemia; DNA topoisomerase II inhibitors; ACUTE LYMPHOBLASTIC-LEUKEMIA; CHRONIC MYELOGENOUS LEUKEMIA; ACUTE MYELOID-LEUKEMIA; HODGKINS-DISEASE; THERAPY; AGENTS; MYELODYSPLASIA; EXPRESSION; ONSET;
D O I
10.1038/sj.leu.2400769
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Therapy with DNA topoisomerase II inhibitors has been shown to result in an increased risk of acute myeloid leukemia (AML), often presenting balanced translocations to chromosome bands 11q23 and 21q22. Also other balanced aberrations, more rarely observed in therapy-related AML (t-AML), such as t(15;17) and inv(16) have been associated with these drugs. Recently we observed a case of chronic myeloid leukemia (CML) with t(9;22) after therapy of a germ cell tumor with etoposide, cisplatin and bleomycin. Based on this case and a review of chemotherapy-related leukemias with t(9;22) from the literature, we suggest a causal relationship between therapy with DNA topoisomerase II inhibitors and development of various types of leukemia carrying the Philadelphia chromosome.
引用
收藏
页码:1571 / 1574
页数:4
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