Thiazolidinediones: an update

被引：174

作者：

Schoonjans, K ^{[1
]}

Auwerx, J ^{[1
]}

机构：

[1] Inst Genet & Biol Mol & Cellulaire, F-67404 Illkirch Graffenstaden, France

来源：

LANCET | 2000年 / 355卷 / 9208期

关键词：

D O I：

10.1016/S0140-6736(00)90002-3

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Thiazolidinediones, which are being developed for the treatment of insulin resistance and type 2 diabetes mellitus bind and activate peroxisome proliferator-activated receptor gamma, a nuclear receptor that regulates the expression of several genes involved in metabolism. This receptor controls adipocyte differentation, lipid storage, and insulin sensitisation. Besides metabolic activities, thiazolidinediones have effects as diverse as the control of host defence :ell proliferation, and tumorigenesis.

引用

页码：1008 / 1010

页数：3

共 34 条

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