Thiazolidinediones: an update

被引：174

作者：

Schoonjans, K ^{[1
]}

Auwerx, J ^{[1
]}

机构：

[1] Inst Genet & Biol Mol & Cellulaire, F-67404 Illkirch Graffenstaden, France

来源：

LANCET | 2000年 / 355卷 / 9208期

关键词：

D O I：

10.1016/S0140-6736(00)90002-3

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Thiazolidinediones, which are being developed for the treatment of insulin resistance and type 2 diabetes mellitus bind and activate peroxisome proliferator-activated receptor gamma, a nuclear receptor that regulates the expression of several genes involved in metabolism. This receptor controls adipocyte differentation, lipid storage, and insulin sensitisation. Besides metabolic activities, thiazolidinediones have effects as diverse as the control of host defence :ell proliferation, and tumorigenesis.

引用

页码：1008 / 1010

页数：3

共 34 条

[21] BM 17.0744:: A structurally new antidiabetic compound with insulin-sensitizing and lipid-lowering activity
Pill, J
Kühnle, HF
[J]. METABOLISM-CLINICAL AND EXPERIMENTAL, 1999, 48 (01): : 34 - 40
[22] Troglitazone - A review of its use in the management of type 2 diabetes mellitus
Plosker, GL
Faulds, D
[J]. DRUGS, 1999, 57 (03) : 409 - 438
[23] Obesity associated with a mutation in a genetic regulator of adipocyte differentiation
Ristow, M
Müller-Wieland, D
Pfeiffer, A
Krone, W
Kahn, CR
[J]. NEW ENGLAND JOURNAL OF MEDICINE, 1998, 339 (14) : 953 - 959
[24] PPARγ is required for the differentiation of adipose tissue in vivo and in vitro
Rosen, ED
Sarraf, P
Troy, AE
Bradwin, G
Moore, K
Milstone, DS
Spiegelman, BM
Mortensen, RM
[J]. MOLECULAR CELL, 1999, 4 (04) : 611 - 617
[25] Activators of the nuclear receptor PPARγ enhance colon polyp formation
Saez, E
Tontonoz, P
Nelson, MC
Alvarez, JGA
U, TM
Baird, SM
Thomazy, VA
Evans, RM
[J]. NATURE MEDICINE, 1998, 4 (09) : 1058 - 1061
[26] Effect of troglitazone in insulin-treated patients with type II diabetes mellitus
Schwartz, S
Raskin, P
Fonseca, V
Graveline, JF
[J]. NEW ENGLAND JOURNAL OF MEDICINE, 1998, 338 (13) : 861 - 866
[27] Pharmacological profiles of a novel oral antidiabetic agent, JTT-501, an isoxazolidinedione derivative
Shibata, T
Matsui, K
Nagao, K
Shinkai, H
Yonemori, F
Wakitani, K
[J]. EUROPEAN JOURNAL OF PHARMACOLOGY, 1999, 364 (2-3) : 211 - 219
[28] An autopsy case of troglitazone-induced fulminant hepatitis
Shibuya, A
Watanabe, M
Fujita, Y
Saigenji, K
Kuwao, S
Takahashi, H
Takeuchi, H
[J]. DIABETES CARE, 1998, 21 (12) : 2140 - 2143
[29] Insulin resistance and diabetes mellitus in transgenic mice expressing nuclear SREBP-1c in adipose tissue: model for congenital generalized lipodystrophy
Shimomura, I
Hammer, RE
Richardson, JA
Ikemoto, S
Bashmakov, Y
Goldstein, JL
Brown, MS
[J]. GENES & DEVELOPMENT, 1998, 12 (20) : 3182 - 3194
[30] Adipogenesis and obesity: Rounding out the big picture
Spiegelman, BM
Flier, JS
[J]. CELL, 1996, 87 (03) : 377 - 389

← 1 2 3 4 →