Serum levels of irisin in gestational diabetes mellitus during pregnancy and after delivery

被引:80
作者
Ebert, Thomas [1 ,2 ]
Stepan, Holger [3 ]
Schrey, Susanne [3 ]
Kralisch, Susan [1 ,2 ]
Hindricks, Janka [1 ,2 ]
Hopf, Lisa [1 ,2 ]
Platz, Martin [1 ,2 ]
Lossner, Ulrike [1 ,2 ]
Jessnitzer, Beate [1 ]
Drewlo, Sascha [4 ]
Blueher, Matthias [1 ]
Stumvoll, Michael [1 ]
Fasshauer, Mathias [1 ,2 ]
机构
[1] Univ Leipzig, Dept Endocrinol & Nephrol, D-04103 Leipzig, Germany
[2] Univ Leipzig, Med Ctr, IFB AdiposityDis, D-04103 Leipzig, Germany
[3] Univ Leipzig, Dept Obstet, D-04103 Leipzig, Germany
[4] Wayne State Univ, Sch Med, Ctr Trophoblast Res, Detroit, MI USA
关键词
Gestational diabetes mellitus; Irisin; Myokine; Pregnancy; OBESITY; RESISTANCE; EXPRESSION; GLUCOSE; TISSUE; LEPTIN; PLASMA;
D O I
10.1016/j.cyto.2013.11.009
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Objective: Irisin has recently been introduced as a novel an exercise-inducible myokine which improves glucose metabolism in mice. However, regulation of circulating irisin in gestational diabetes mellitus (GDM) and in the peripartal period has not been assessed so far. Methods: Circulating irisin was quantified in 74 GDM patients and in 74 healthy, pregnant, gestational age-matched controls. In a subset of these patients (44 GDM, 41 controls), postpartum follow-up data were also available. In a second study population of 40 healthy women with singleton pregnancies undergoing elective Cesarean section, irisin was assessed in maternal serum before and within 24 h after delivery, as well as in umbilical cord blood and in placental tissue. Results: In the first study population, median [interquartile range] irisin levels were significantly higher in GDM patients as compared to controls after delivery (previous GDM: 446.3 [146.9] mu g/l; controls: 378.0 [111.4] mu g/l) but not during pregnancy (GDM: 482.1 [132.1] mu g/l; controls: 466.6 [178.0] mu g/l). Interestingly, fasting insulin (FI) was independently and positively associated with serum irisin in multivariate analysis during pregnancy. In agreement with these findings, relative changes (ratio) of FI independently and positively predicted relative changes of irisin (ratio) in the second study population. Conclusions: The myokine irisin is independently associated with FI in pregnancy. The physiological significance of these findings needs to be assessed in future experiments. (C) 2013 Elsevier Ltd. All rights reserved.
引用
收藏
页码:153 / 158
页数:6
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