Automated medicinal chemistry

被引：24

作者：

Koppitz, Marcus ^{[1
]}

Eis, Knut ^{[1
]}

机构：

[1] Schering AG, Med Chem, D-13342 Berlin, Germany

来源：

DRUG DISCOVERY TODAY | 2006年 / 11卷 / 11-12期

关键词：

D O I：

10.1016/j.drudis.2006.04.005

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

With the advent of high throughput technologies in biological screening in the 1980s, providing sufficient numbers of small molecules for screening became a bottleneck in the drug discovery process. Combinatorial chemistry was the first attempt by chemists to address this issue. However, since its first applications, combinatorial chemistry has evolved rapidly into diverse fields. This review will focus on the evolution and the current status of what we refer to today as automated medicinal chemistry.

引用

收藏

页码：561 / 568

页数：8

相关论文

共 70 条

[1] Reproducibility across microwave instruments:: Preparation of a set of 24 compounds on a multiwell plate under temperature-controlled conditions [J].

Alcázer, J .

JOURNAL OF COMBINATORIAL CHEMISTRY, 2005, 7 (03) :353-355

[2] Hit and lead generation:: Beyond high-throughput screening [J].

Bleicher, KH ;

Böhm, HJ ;

Müller, K ;

Alanine, AI .

NATURE REVIEWS DRUG DISCOVERY, 2003, 2 (05) :369-378

[3] Preparative LC-MS purification: Improved compound-specific method optimization [J].

Blom, KF ;

Glass, B ;

Sparks, R ;

Combs, AP .

JOURNAL OF COMBINATORIAL CHEMISTRY, 2004, 6 (06) :874-883

[4] Optimizing preparative LC/MS configurations and methods for parallel synthesis purification [J].

Blom, KF ;

Sparks, R ;

Doughty, J ;

Everlof, JG ;

Haque, T ;

Combs, AP .

JOURNAL OF COMBINATORIAL CHEMISTRY, 2003, 5 (05) :670-683

[5] Classifying "kinase inhibitor-likeness" by using machine-learning methods [J].

Briem, H ;

Günther, J .

CHEMBIOCHEM, 2005, 6 (03) :558-566

[6] Increasing the efficiency of small-molecule drug discovery [J].

Bunin, BA .

DRUG DISCOVERY TODAY, 2003, 8 (18) :823-826

[7] A GENERAL AND EXPEDIENT METHOD FOR THE SOLID-PHASE SYNTHESIS OF 1,4-BENZODIAZEPINE DERIVATIVES [J].

BUNIN, BA ;

ELLMAN, JA .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1992, 114 (27) :10997-10998

[8] Work-up strategies for high-throughput solution synthesis [J].

Cork, D ;

Hird, N .

DRUG DISCOVERY TODAY, 2002, 7 (01) :56-63

[9]

Cullen CJ, 2004, CURR OPIN DRUG DISC, V7, P798

[10] Heterogeneous hydrogenation reactions using a continuous flow high pressure device [J].

Desai, B ;

Kappe, CO .

JOURNAL OF COMBINATORIAL CHEMISTRY, 2005, 7 (05) :641-643

← 1 2 3 4 5 6 7 →