Biomarker discovery by comprehensive phenotyping for autoimmune diseases

被引：24

作者：

Kantor, AB ^{[1
]}

Wang, WX ^{[1
]}

Lin, H ^{[1
]}

Govindarajan, H ^{[1
]}

Anderle, M ^{[1
]}

Perrone, A ^{[1
]}

Becker, C ^{[1
]}

机构：

[1] SurroMed Inc, Menlo Pk, CA 94025 USA

来源：

CLINICAL IMMUNOLOGY | 2004年 / 111卷 / 02期

关键词：

biomarkers; cytometry proteomics; mass spectrometry; clinical studies; autoimmune disease; rheumatoid arthritis;

D O I：

10.1016/j.clim.2003.12.011

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

There is a well-reconized but unmet need for biological markers to characterize disease type, status, progression, and response to therapy in autoimmune diseases. We are developing and applying an integrated bioanalytical platform and clinical research program to facilitate comprehensive differential phenotyping of patient samples and enable the discovery of biomarkers. Our measurement platform includes microvolume laser scanning cytometry for the quantification of hundreds of cellular parameters in whole blood and other samples, liquid chromatography-mass spectrometry and gas chromatography-mass spectrometry for the quantification of proteins and low molecular weight biomolecules in serum and other fluids or tissues, and specific inununoassays for the quantification of trace proteins in serum. We describe the technologies and discuss initial applications to the analysis of subjects with rheumatoid arthritis (RA) and healthy controls. (C) 2004 Elsevier Inc. All rights reserved.

引用

页码：186 / 195

页数：10

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