New and selective ryanodine receptor activators for insect control

被引：581

作者：

Lahm, George P. ^{[1
]}

Cordova, Daniel ^{[1
]}

Barry, James D. ^{[1
]}

机构：

[1] DuPont Crop Protect, Stine Haskell Res Ctr, Newark, DE 19711 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY | 2009年 / 17卷 / 12期

关键词：

Ryanodine; Insecticide; Flubendiamide; Chlorantraniliprole; Rynaxypyr; ANTHRANILIC DIAMIDE; CHANNEL; FLUBENDIAMIDE; POTENT; MODE;

D O I：

10.1016/j.bmc.2009.01.018

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Diamide insecticides have emerged as one of the most promising new classes of insecticide chemistry owing to their excellent insecticidal efficacy and high margins of mammalian safety. Chlorantraniliprole and flubendiamide, the first two insecticides from this class, demonstrate exceptional activity across a broad range of pests in the order Lepidoptera. This chemistry has been confirmed to control insects via activation of ryanodine receptors which leads to uncontrolled calcium release in muscle. The high levels of mammalian safety are attributed to a strong selectivity for insect over mammalian receptors. (C) 2009 Elsevier Ltd. All rights reserved.

引用

页码：4127 / 4133

页数：7

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