T-cells specific for soluble recombinant oligodendrocyte-specific protein induce severe clinical experimental autoimmune encephalomyelitis in H-2b and H-2s mice

被引：26

作者：

Zhong, MC

Cohen, L

Meshorer, A

de Rosbo, NK

Ben-Nun, A ^{[1
]}

机构：

[1] Weizmann Inst Sci, Dept Immunol, IL-76100 Rehovot, Israel

[2] Weizmann Inst Sci, Dept Biol Serv, IL-76100 Rehovot, Israel

来源：

JOURNAL OF NEUROIMMUNOLOGY | 2000年 / 105卷 / 01期

关键词：

experimental autoimmune encephalomyelitis; oligodendrocyte-specific protein; multiple sclerosis; central nervous system; T-cell response;

D O I：

10.1016/S0165-5728(00)00186-7

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

To investigate the immunogenicity and encephalitogenicity of oligodendrocyte-specific protein (OSP), recombinant soluble mouse OSP (smOSP) was produced from a synthetic gene engineered to lack the sequences coding for the hydrophobic transmembrane domains of the native molecule. SmOSP was immunogenic and encephalitogenic for SJL/J, C3H.SW and C57BL/6J mice, but not PL/J or BALB/c mice. SmOSP-specific T-cells from SJL/J, C3H.SW and C57BL/6J mice induced severe chronic clinical experimental autoimmune encephalomyelitis upon transfer. These findings indicate that autoimmune T-cell responses to OSP should be investigated in the context of multiple sclerosis. (C) 2000 Elsevier Science B.V. All rights reserved.

引用

页码：39 / 45

页数：7