Calcium Signalling: Mitofusins Promote Interorganellar Crosstalk

被引：15

作者：

Parekh, Anant ^{[1
]}

机构：

[1] Univ Oxford, Dept Physiol Anat & Genet, Oxford, England

来源：

CURRENT BIOLOGY | 2009年 / 19卷 / 05期

关键词：

ENDOPLASMIC-RETICULUM; CA2+ CHANNELS; MITOCHONDRIA; MICRODOMAINS; ER; HOMEOSTASIS; APOPTOSIS; DYNAMICS; FUSION; STORE;

D O I：

10.1016/j.cub.2009.01.012

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Juxtaposition of the endoplasmic reticulum with mitochondria facilitates Ca(2+) fluxes between the organelles. However, the molecular basis of interorganellar tethering remains unknown. A recent report has identified a fundamental role for the dynamin-related mitofusins in the tethering mechanism, thereby ensuring rapid and high fidelity Ca(2+) signalling between the organelles.

引用

页码：R200 / R203

页数：4

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