Protein-facilitated RNA folding

被引：108

作者：

Weeks, KM

机构：

[1] Department of Chemistry, University of North Carolina, Chapel Hill

来源：

CURRENT OPINION IN STRUCTURAL BIOLOGY | 1997年 / 7卷 / 03期

关键词：

D O I：

10.1016/S0959-440X(97)80048-6

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In the absence of protein collaborators, both simple and complex RNAs often misfold or are unfolded. Biologically important RNAs solve their folding problem, in part, using the assistance of chaperone and cofactor proteins. Recent work emphasizes several rules for RNA-protein complexes: formation involves induced fit; many large RNAs fold slowly; and ribonucleoprotein assembly requires multiple steps. Finally, protein binding can introduce thermodynamic side effects. (C) Current Biology Ltd.

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页码：336 / 342

页数：7

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