Osteogenic activity and antibacterial effect of porous titanium modified with metal-organic framework films

被引:158
作者
Chen, Junyu [1 ,2 ]
Zhang, Xin [1 ,2 ,3 ]
Huang, Chao [3 ]
Cai, He [1 ,2 ]
Hu, Shanshan [1 ,2 ]
Wan, Qianbing [1 ,2 ]
Pei, Xibo [1 ,2 ]
Wang, Jian [1 ,2 ]
机构
[1] Sichuan Univ, West China Hosp Stomatol, State Key Lab Oral Dis, Chengdu 610041, Sichuan, Peoples R China
[2] Sichuan Univ, West China Hosp Stomatol, Dept Prosthodont, Chengdu 610041, Sichuan, Peoples R China
[3] Sichuan Univ, Coll Chem, Chengdu 610041, Sichuan, Peoples R China
基金
中国国家自然科学基金;
关键词
metal-organic frameworks; film; titanium modification; osteogenic activity; antibacterial effect; MESENCHYMAL STEM-CELLS; IN-VITRO; OSTEOBLASTIC DIFFERENTIATION; SURFACE-PROPERTIES; CALCIUM-PHOSPHATE; TREATED TITANIUM; GROWTH; HYDROXYAPATITE; NANOPARTICLES; IMPLANTS;
D O I
10.1002/jbm.a.35960
中图分类号
R318 [生物医学工程];
学科分类号
100103 [病原生物学];
摘要
As a new class of crystalline nanoporous materials, metal-organic frameworks (MOFs) have recently been used for biomedical applications due to their large surface area, high porosity, and theoretically infinite structures. To improve the biological performance of titanium, MOF films were applied to surface modification of titanium. Zn-based MOF films composed of zeolitic imidazolate framework-8 (ZIF-8) crystals with nanoscale and microscale sizes (nanoZIF-8 and microZIF-8) were prepared on porous titanium surfaces by hydrothermal and solvothermal methods, respectively. The ZIF-8 films were characterized by powder X-ray diffraction (PXRD), Fourier transform infrared spectroscopy (FTIR), and scanning electron microscopy (SEM). The nanoZIF-8 film exhibited good biocompatibility, whereas the microZIF-8 film showed obvious cytotoxicity to MG63 cells. Compared to pure titanium and alkali- and heat-treated porous titanium, the nanoZIF-8 film not only enhanced alkaline phosphatase (ALP) activity, extracellular matrix mineralization, and expression of osteogenic genes (ALP, Runx2) in MG63 cells but also inhibited the growth of Streptococcus mutans. These results indicate that MOF films or coatings may be promising candidates for bone tissue engineering. (c) 2016 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 105A: 834-846, 2017.
引用
收藏
页码:834 / 846
页数:13
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