Function of the spalt/spalt-related gene complex in positioning the veins in the Drosophila wing

被引:80
作者
de Celis, JF
Barrio, R
机构
[1] European Mol Biol Lab, D-69117 Heidelberg, Germany
[2] Univ Cambridge, Dept Genet, Cambridge CB2 3EH, England
基金
英国惠康基金;
关键词
spalt; vein; iroquois; knirps;
D O I
10.1016/S0925-4773(99)00261-0
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
Spalt and Spalt-related encode conserved Zn-finger proteins that mediate the function of the TGF-beta molecule Decapentaplegic during the positioning of veins in the Drosophila wing. Here we show that Spalt and Spalt-related regulate the vein-specific expression of the transcription factors of the knirps and iroquois gene complexes, delimiting their domains of expression in the wing pouch. The effects of spalt/spalt-related mutations on knirps and iroquois expression are cell-autonomous, suggesting that they could be direct. The regulation of iroquois involves transcriptional repression by Spalt and Spalt-related, whereas the regulation of knirps involves a combination of transcriptional activation and repression mediated by the same genes. We suggest that the regulation of the iroquois and knirps gene complexes by Spalt and Spalt-related translates the Decapentaplegic morphogenetic gradient into precisely spaced pattern elements. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.
引用
收藏
页码:31 / 41
页数:11
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