Pathway of chymotrypsin evolution suggested by the structure of the FMN-binding protein from Desulfovibrio vulgaris (Miyazaki F)

被引：45

作者：

Liepinsh, E

Kitamura, M

Murakami, T

Nakaya, T

Otting, G

机构：

[1] KAROLINSKA INST,DEPT MED BIOCHEM & BIOPHYS,S-17177 STOCKHOLM,SWEDEN

[2] OSAKA CITY UNIV,FAC ENGN,DEPT BIOAPPL CHEM,OSAKA 558,JAPAN

[3] OSAKA CITY UNIV,FAC ENGN,DEPT BIOAPPL CHEM,SUMIYOSHI KU,OSAKA 558,JAPAN

来源：

NATURE STRUCTURAL BIOLOGY | 1997年 / 4卷 / 12期

关键词：

D O I：

10.1038/nsb1297-975

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The flavin mononucleotide (FMN)-binding protein from Desulfovibrio vulgaris (Miyazaki F) is structurally related to a so far hypothetical single-domain precursor of chymotrypsin, with the FMN-binding site coinciding with part of the active site of the protease.

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页码：975 / 979

页数：5

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