Mitotic misregulation and human aging

被引：462

作者：

Ly, DH

Lockhart, DJ

Lerner, RA

Schultz, PG

机构：

[1] Scripps Res Inst, Dept Chem, La Jolla, CA 92037 USA

[2] Scripps Res Inst, Skaggs Inst Chem Biol, La Jolla, CA 92037 USA

[3] Novartis Res Fdn, Genom Inst, San Diego, CA 92121 USA

来源：

SCIENCE | 2000年 / 287卷 / 5462期

关键词：

D O I：

10.1126/science.287.5462.2486

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Messenger RNA Levels were measured in actively dividing fibroblasts isolated from young, middle-age, and old-ago humans and humans with progeria, a rare genetic disorder characterized by accelerated aging. Genes whose expression is associated with age-related phenotypes and diseases were identified. The data also suggest that an underlying mechanism of the aging process involves increasing errors in the mitotic machinery of dividing cells in the postreproductive stage of Life. We propose that this dysfunction leads to chromosomal pathologies that result in misregulation of genes involved in the aging process.

引用

页码：2486 / 2492

页数：7

共 47 条

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