Cardiovascular remodelling in coronary artery disease and heart failure

被引：709

作者：

Heusch, Gerd ^{[1
]}

Libby, Peter ^{[2
]}

Gersh, Bernard ^{[3
,4
]}

Yellon, Derek ^{[5
]}

Boehm, Michael ^{[6
]}

Lopaschuk, Gary ^{[7
]}

Opie, Lionel ^{[8
]}

机构：

[1] Univ Klinikum Essen, Inst Pathophysiol, Essen, Germany

[2] Harvard Univ, Brigham & Womens Hosp, Sch Med, Boston, MA 02115 USA

[3] Mayo Clin, Div Cardiovasc Dis, Rochester, MN USA

[4] Mayo Clin, Coll Med, Rochester, MN USA

[5] UCL, Hatter Cardiovasc Inst, London, England

[6] Univ Klinikum Saarlandes, Innere Med Klin 3, Homburg, Germany

[7] Univ Alberta, Mazankowski Alberta Heart Inst, Edmonton, AB, Canada

[8] Univ Cape Town, Hatter Inst Cardiovasc Res Africa, ZA-7925 Cape Town, Western Cape, South Africa

来源：

LANCET | 2014年 / 383卷 / 9932期

关键词：

ELEVATION MYOCARDIAL-INFARCTION; LEFT-VENTRICULAR HYPERTROPHY; RANDOMIZED CONTROLLED-TRIAL; RENAL SYMPATHETIC DENERVATION; SMOOTH-MUSCLE CELLS; FAILING HUMAN HEART; MYOSIN HEAVY-CHAIN; REPERFUSION INJURY; FATTY-ACID; NO-REFLOW;

D O I：

10.1016/S0140-6736(14)60107-0

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Remodelling is a response of the myocardium and vasculature to a range of potentially noxious haemodynamic, metabolic, and inflammatory stimuli. Remodelling is initially functional, compensatory, and adaptive but, when sustained, progresses to structural changes that become self-perpetuating and pathogenic. Remodelling involves responses not only of the cardiomyocytes, endothelium, and vascular smooth muscle cells, but also of interstitial cells and matrix. In this Review we characterise the remodelling processes in atherosclerosis, vascular and myocardial ischaemia-reperfusion injury, and heart failure, and we draw attention to potential avenues for innovative therapeutic approaches, including conditioning and metabolic strategies.

引用

页码：1933 / 1943

页数：11

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