One-pot synthesis of 3,4-disubstituted 1H-pyrroles from 2-tropanones

被引：14

作者：

Airaksinen, AJ ^{[1
]}

Ahlgren, M

Vepsäläinen, J

机构：

[1] Univ Kuopio, Dept Chem, FIN-70211 Kuopio, Finland

[2] Univ Joensuu, Dept Chem, FIN-80101 Joensuu, Finland

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2002年 / 67卷 / 14期

关键词：

D O I：

10.1021/jo0257703

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

3,4-Disubstituted pyrroles (2, 3) were prepared from 6/7-carboxyethyl-3-phenyl-3-tropen-2-ones (1) regioselectively and with high yields by using tosylmethyl isocyanide (TosMIC). This procedure enables the synthesis of pyrroles substituted with two distinct groups: a phenyl group and a substituted pyrrolidine analogue. The crystal structure of product 2a was determined, and the analogous derivatives were identified by H-1 and C-13 NMR spectroscopy.

引用

页码：5019 / 5021

页数：3

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