4-Hydroxynonenal (4-HNE) has been widely accepted as an inducer of oxidative stress. Is this the whole truth about it or can 4-HNE also exert protective effects?

被引:54
作者
Chen, ZH [1 ]
Niki, E [1 ]
机构
[1] Natl Inst Adv Ind Sci & Technol, AIST, HSSRC, Ikeda, Osaka 5638577, Japan
关键词
D O I
10.1080/15216540600686896
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
引用
收藏
页码:372 / 373
页数:2
相关论文
共 18 条
[1]   Regulation of 4-hydroxynonenal-mediated signaling by glutathione S-transferases [J].
Awasthi, YC ;
Yang, YS ;
Tiwari, NK ;
Patrick, B ;
Sharma, A ;
Li, J ;
Awasthi, S .
FREE RADICAL BIOLOGY AND MEDICINE, 2004, 37 (05) :607-619
[2]   4-hydroxynonenal and regulation of cell cycle: Effects on the pRb/E2F pathway [J].
Barrera, G ;
Pizzimenti, S ;
Dianzani, MU .
FREE RADICAL BIOLOGY AND MEDICINE, 2004, 37 (05) :597-606
[3]   Adaptive response induced by lipid peroxidation products in cell cultures [J].
Chen, ZH ;
Yoshida, Y ;
Saito, Y ;
Noguchi, N ;
Niki, E .
FEBS LETTERS, 2006, 580 (02) :479-483
[4]   4-Hydroxynonenal induces adaptive response and enhances PC12 cell tolerance primarily through induction of thioredoxin reductase 1 via activation of Nrf2 [J].
Chen, ZH ;
Saito, Y ;
Yoshida, Y ;
Sekine, A ;
Noguchi, N ;
Niki, E .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2005, 280 (51) :41921-41927
[5]  
Davies KJA, 1999, IUBMB LIFE, V48, P41, DOI 10.1080/152165499307404
[6]   4-hydroxynonenal induces glutamate cysteine ligase through JNK in HBE1 cells [J].
Dickinson, DA ;
Iles, KE ;
Watanabe, N ;
Iwamoto, T ;
Zhang, HQ ;
Krzywanski, DM ;
Forman, HJ .
FREE RADICAL BIOLOGY AND MEDICINE, 2002, 33 (07) :974-987
[7]   CHEMISTRY AND BIOCHEMISTRY OF 4-HYDROXYNONENAL, MALONALDEHYDE AND RELATED ALDEHYDES [J].
ESTERBAUER, H ;
SCHAUR, RJ ;
ZOLLNER, H .
FREE RADICAL BIOLOGY AND MEDICINE, 1991, 11 (01) :81-128
[8]   Cellular response to the redox active lipid peroxidation products: Induction of glutathione S-transferase P by 4-hydroxy-2-nonenal [J].
Fukuda, A ;
Nakamura, Y ;
Ohigashi, H ;
Osawa, T ;
Uchida, K .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1997, 236 (02) :505-509
[9]   HNE increases HO-1 through activation of the ERK pathway in pulmonary epithelial cells [J].
Iles, KE ;
Dickinson, DA ;
Wigley, AF ;
Welty, NE ;
Blank, V ;
Forman, HJ .
FREE RADICAL BIOLOGY AND MEDICINE, 2005, 39 (03) :355-364
[10]   Role of Nrf2 in the regulation of CD36 and stress protein expression in murine macrophages - Activation by oxidatively modified LDL and 4-hydroxynonenal [J].
Ishii, T ;
Itoh, K ;
Ruiz, E ;
Leake, DS ;
Unoki, H ;
Yamamoto, M ;
Mann, GE .
CIRCULATION RESEARCH, 2004, 94 (05) :609-616