The diversity of costimulatory and inhibitory receptor pathways and the regulation of antiviral T cell responses

被引:124
作者
Crawford, Alison [1 ]
Wherry, E. John [1 ]
机构
[1] Wistar Inst Anat & Biol, Program Immunol, Philadelphia, PA 19104 USA
基金
美国国家卫生研究院;
关键词
PD-1; EXPRESSION; UP-REGULATION; LYMPHOCYTE ATTENUATOR; B-LYMPHOCYTE; CD4(+); CTLA-4; CD28; DYSFUNCTION; ACTIVATION; EXHAUSTION;
D O I
10.1016/j.coi.2009.01.010
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
T cell responses are regulated by integrating positive and negative signals from costimulatory and inhibitory receptors. While the function of specific T cell costimulatory molecules during infections has been appreciated for some time, recent observations have now revealed a crucial role for inhibitory receptors in regulating T cell responses to pathogens, especially during chronic infections. A key emerging principle is that there is considerable diversity in the number and type of inhibitory receptors that can be expressed by T cells during both acute and chronic infections. These distinct inhibitory pathways appear to cooperate in regulating T cell function, could have distinct mechanisms of action, and are likely to provide novel therapeutic targets during persisting infections and other diseases.
引用
收藏
页码:179 / 186
页数:8
相关论文
共 65 条
[1]  
Bachmann MF, 1998, J IMMUNOL, V160, P95
[2]   Restoring function in exhausted CD8 T cells during chronic viral infection [J].
Barber, DL ;
Wherry, EJ ;
Masopust, D ;
Zhu, BG ;
Allison, JP ;
Sharpe, AH ;
Freeman, GJ ;
Ahmed, R .
NATURE, 2006, 439 (7077) :682-687
[3]   Role of T cell costimulation in anti-viral immunity [J].
Bertram, EM ;
Dawicki, W ;
Watts, TH .
SEMINARS IN IMMUNOLOGY, 2004, 16 (03) :185-196
[4]  
BLACKBURN SD, 2008, NAT IMMUNOL
[5]   Expression of the interleukin-7 receptor alpha chain (CD127) on virus-specific CD8+ T cells identifies functionally and phenotypically defined memory T cells during acute resolving hepatitis B virus infection [J].
Boettler, T ;
Panther, E ;
Bengsch, B ;
Nazarova, N ;
Spangenberg, HC ;
Blum, HE ;
Thimme, R .
JOURNAL OF VIROLOGY, 2006, 80 (07) :3532-3540
[6]   Characterization of hepatitis B virus (HBV)-specific T-cell dysfunction in chronic HBV infection [J].
Boni, Carolina ;
Fisicaro, Paola ;
Valdatta, Caterina ;
Amadei, Barbara ;
Di Vincenzo, Paola ;
Giuberti, Tiziana ;
Laccabue, Diletta ;
Zerbini, Alessandro ;
Cavalli, Albertina ;
Missale, Gabriele ;
Bertoletti, Antonio ;
Ferrari, Carlo .
JOURNAL OF VIROLOGY, 2007, 81 (08) :4215-4225
[7]  
Brunner MC, 1999, J IMMUNOL, V162, P5813
[8]   Programmed death-1 ligand 1 interacts specifically with the B7-1 costimulatory molecule to inhibit T cell responses [J].
Butte, Manish J. ;
Keir, Mary E. ;
Phamduy, Theresa B. ;
Sharpe, Arlene H. ;
Freeman, Gordon J. .
IMMUNITY, 2007, 27 (01) :111-122
[9]   CD160 inhibits activation of human CD4+ T cells through interaction with herpesvirus entry mediator [J].
Cai, Guifang ;
Anumanthan, Anukanth ;
Brown, Julia A. ;
Greenfield, Edward A. ;
Zhu, Baogong ;
Freeman, Gordon J. .
NATURE IMMUNOLOGY, 2008, 9 (02) :176-185
[10]  
Carter LL, 2002, EUR J IMMUNOL, V32, P634, DOI 10.1002/1521-4141(200203)32:3<634::AID-IMMU634>3.0.CO