Spiroquinazolinones as novel, potent, and selective PDE7 inhibitors. Part 1

被引：39

作者：

Lorthiois, E

Bernardelli, P

Vergne, F

Oliveira, C

Mafroud, AK

Proust, E

Heuze, L

Moreau, F

Idrissi, M

Tertre, A

Bertin, B

Coupe, M

Wrigglesworth, R

Descours, A

Soulard, P

Berna, P

机构：

[1] Pfizer Global Res & Dev, F-94265 Fresnes, France

[2] Pfizer Discovery Technol Ctr, Cambridge, MA 02139 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2004年 / 14卷 / 18期

关键词：

PDE7; phosphodiesterase;

D O I：

10.1016/j.bmcl.2004.07.011

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The synthesis and SAR studies of spiroquinazolinones as novel PDE7 inhibitors are discussed. The best compounds from the series displayed nanomolar inhibitory affinity and were selective versus other PDE isoenzymes. (C) 2004 Elsevier Ltd. All rights reserved.

引用

页码：4623 / 4626

页数：4

共 23 条

[21] Regulation of cAMP and cGMP signaling: new phosphodiesterases and new functions [J].