Further checkpoints in Th1 development

被引：168

作者：

Robinson, DS

O'Garra, A

机构：

[1] Natl Inst Med Res, Immunoregulat Lab, London NW7 1AA, England

[2] Univ London Imperial Coll Sci Technol & Med, Fac Med, London SW7 2AK, England

来源：

IMMUNITY | 2002年 / 16卷 / 06期

基金：

英国惠康基金; 英国医学研究理事会;

关键词：

D O I：

10.1016/S1074-7613(02)00331-X

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Tight control of Th1 immunity is essential to prevent immunopathology. Central to control of the IFN-gamma gene is the transcription factor T-bet, whose induction is Stat-1 dependent. IL-12 is dominant in directing Th1 development, while synergizing with IL-18 for IFNgamma production from differentiated Th1 cells. In this issue of Immunity, IL-27 is described, which acts in synergy with IL-12 early in Th1 development from naive T cells via the receptor TCCR/WSX-1. We review the coordination of these checkpoints in Th1 development and function.

引用

收藏

页码：755 / 758

页数：4

相关论文

共 31 条

[1] Functional diversity of helper T lymphocytes [J].

Abbas, AK ;

Murphy, KM ;

Sher, A .

NATURE, 1996, 383 (6603) :787-793

[2] T-bet is a STAT1-induced regulator of IL-12R expression in naive CD4+ T cells [J].

Afkarian, M ;

Sedy, JR ;

Yang, J ;

Jacobson, NG ;

Cereb, N ;

Yang, SY ;

Murphy, TL ;

Murphy, KM .

NATURE IMMUNOLOGY, 2002, 3 (06) :549-557

[3] Development of Th1-type immune responses requires the type I cytokine receptor TCCR [J].

Chen, Q ;

Ghilardi, N ;

Wang, H ;

Baker, T ;

Xie, MH ;

Gurney, A ;

Grewal, IS ;

de Sauvage, FJ .

NATURE, 2000, 407 (6806) :916-920

[4] Epstein-Barr virus-induced gene 3 and the p35 subunit of interleukin 12 form a novel heterodimeric hematopoietin [J].

Devergne, O ;

Birkenbach, M ;

Kieff, E .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1997, 94 (22) :12041-12046

[5] Impairment of Mycobacterial But Not Viral Immunity by a Germline Human STAT1 Mutation [J].

Dupuis, S ;

Dargemont, C ;

Fieschi, C ;

Thomassin, N ;

Rosenzweig, S ;

Harris, J ;

Holland, SM ;

Schreiber, RD ;

Casanova, JL .

SCIENCE, 2001, 293 (5528) :300-303

[6] Development of spontaneous airway changes consistent with human asthma in mice lacking T-bet [J].

Finotto, S ;

Neurath, MF ;

Glickman, JN ;

Qin, SX ;

Lehr, HA ;

Green, FHY ;

Ackerman, K ;

Haley, K ;

Gatte, PR ;

Szabo, SJ ;

Drazen, JM ;

De Sanctis, GT ;

Glimcher, LH .

SCIENCE, 2002, 295 (5553) :336-338

[7] Early transcription and silencing of cytokine genes underlie polarization of T helper cell subsets [J].

Grogan, JL ;

Mohrs, M ;

Harmon, B ;

Lacy, DA ;

Sedat, JW ;

Locksley, RM .

IMMUNITY, 2001, 14 (03) :205-215

[8] Cutting edge:: Ectopic expression of the IL-12 receptor-β2 in developing and committed Th2 cells does not affect the production of IL-4 or induce the production of IFN-γ [J].

Heath, VL ;

Showe, L ;

Crain, C ;

Barrat, FJ ;

Trinchieri, G ;

O'Garra, A .

JOURNAL OF IMMUNOLOGY, 2000, 164 (06) :2861-2865

[9] INTERLEUKIN-12 SIGNALING IN T-HELPER TYPE-1 (TH1) CELLS INVOLVES TYROSINE PHOSPHORYLATION OF SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION (STAT)3 AND STAT4 [J].

JACOBSON, NG ;

SZABO, SJ ;

WEBERNORDT, RM ;

ZHONG, Z ;

SCHREIBER, RD ;

DARNELL, JE ;

MURPHY, KM .

JOURNAL OF EXPERIMENTAL MEDICINE, 1995, 181 (05) :1755-1762

[10] Interferon-gamma-receptor deficiency in an infant with fatal bacille Calmette-Guerin infection [J].

Jouanguy, E ;

Altare, F ;

Lamhamedi, S ;

Revy, P ;

Emile, JF ;

Newport, M ;

Levin, M ;

Blanche, S ;

Seboun, E ;

Fischer, A ;

Casanova, JL .

NEW ENGLAND JOURNAL OF MEDICINE, 1996, 335 (26) :1956-1961

← 1 2 3 4 →