Further checkpoints in Th1 development

被引：168

作者：

Robinson, DS

O'Garra, A

机构：

[1] Natl Inst Med Res, Immunoregulat Lab, London NW7 1AA, England

[2] Univ London Imperial Coll Sci Technol & Med, Fac Med, London SW7 2AK, England

来源：

IMMUNITY | 2002年 / 16卷 / 06期

基金：

英国惠康基金; 英国医学研究理事会;

关键词：

D O I：

10.1016/S1074-7613(02)00331-X

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Tight control of Th1 immunity is essential to prevent immunopathology. Central to control of the IFN-gamma gene is the transcription factor T-bet, whose induction is Stat-1 dependent. IL-12 is dominant in directing Th1 development, while synergizing with IL-18 for IFNgamma production from differentiated Th1 cells. In this issue of Immunity, IL-27 is described, which acts in synergy with IL-12 early in Th1 development from naive T cells via the receptor TCCR/WSX-1. We review the coordination of these checkpoints in Th1 development and function.

引用

收藏

页码：755 / 758

页数：4

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