Expression of ErbB3, ErbB4, and neuregulin-1 mRNA during tooth development

被引：12

作者：

Fried, K

Risling, M

Tidcombe, H

Gassmann, M

Lillesaar, C

机构：

[1] Karolinska Inst, Novum, Ctr Oral Biol, S-14104 Huddinge, Sweden

[2] Karolinska Inst, Dept Neurosci, Stockholm, Sweden

[3] Natl Jewish Ctr Immunol & Resp Med, Div Neurobiol, London, England

[4] Linkoping Univ, Fac Hlth Sci, Dept Biomed & Surg, Linkoping, Sweden

来源：

DEVELOPMENTAL DYNAMICS | 2002年 / 224卷 / 03期

关键词：

tooth; development; neuregulin; ErbB3; ErbB4; rat; in situ hybridization; innervation; ErbB4 knockout mice;

D O I：

10.1002/dvdy.10114

中图分类号：

R602 [外科病理学、解剖学]; R32 [人体形态学];

学科分类号：

100101 ;

摘要：

The receptor tyrosine kinases ErbB3 and ErbB4, which bind to various variants of neuregulin (NRG), play fundamental roles in neural development and in organs, which form through epithelial-mesenchymal interactions. Here, we demonstrate that NRG-1 and the receptors ErbB3 and ErbB4 are expressed locally during rodent tooth development. However, the mRNA expression patterns of ErbB3 and ErbB4 were distinctly different during odontogenesis. Examinations of teeth in genetically heart-rescued ErbB4-/- mice did not reveal any obvious deviation from the normal phenotype. The results suggest that ErbB3 and ErbB4 may participate in tooth morphogenesis. The specific interactions between NRG isoforms and ErbB receptors during this process remain to be determined. (C) 2002 Wiley-Liss, Inc.

引用

页码：356 / 360

页数：5

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