Enantioselective organocatalytic tandem Michael-aldol reactions: One-pot synthesis of chiral thiochromenes

被引：374

作者：

Wang, Wei ^{[1
]}

Li, Hao ^{[1
]}

Wang, Jian ^{[1
]}

Zu, Liansuo ^{[1
]}

机构：

[1] Univ New Mexico, Dept Chem, Albuquerque, NM 87131 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2006年 / 128卷 / 32期

关键词：

D O I：

10.1021/ja063328m

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A highly enantioselective (S) diphenylpyrrolinol silyl ether promoted tandem Michael-aldol reaction of α,β-unsaturated aldehydes with 2-mercaptobenzaldehydes has been developed. The method affords one-pot access to chiral and synthetically useful thiochromenes in high yields and high enantioselectivities from readily available compounds. Copyright © 2006 American Chemical Society.

引用

页码：10354 / 10355

页数：2

共 45 条

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