The antimicrobial natural product chuangxinmycin and some synthetic analogues are potent and selective inhibitors of bacterial tryptophanyl tRNA synthetase

被引：131

作者：

Brown, MJ ^{[1
]}

Carter, PS ^{[1
]}

Fenwick, AE ^{[1
]}

Fosberry, AP ^{[1
]}

Hamprecht, DW ^{[1
]}

Hibbs, MJ ^{[1
]}

Jarvest, RL ^{[1
]}

Mensah, L ^{[1
]}

Milner, PH ^{[1
]}

O'Hanlon, PJ ^{[1
]}

Pope, AJ ^{[1
]}

Richardson, CM ^{[1
]}

West, A ^{[1
]}

Witty, DR ^{[1
]}

机构：

[1] GlaxoSmithKline, Harlow CM19 5AW, Essex, England

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2002年 / 12卷 / 21期

关键词：

D O I：

10.1016/S0960-894X(02)00604-2

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The antimicrobial natural product chuangxinmycin has been found to be a potent and selective inhibitor of bacterial tryptophanyl tRNA synthetase (WRS). A number of analogues have been synthesised. The interaction with WRS appears to be highly constrained, as only sterically smaller analogues afforded significant inhibition. The only analogue to show inhibition comparable to chuangxinmycin also had antibacterial activity. WRS inhibition may contribute to the antibacterial action of chuangxinmycin. (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

页码：3171 / 3174

页数：4

共 21 条

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