New target, new drug, old paradigm

被引：19

作者：

Hidalgo, M ^{[1
]}

机构：

[1] Johns Hopkins, Sidney Kimmel Comprehens Canc Ctr, Baltimore, MD USA

来源：

JOURNAL OF CLINICAL ONCOLOGY | 2004年 / 22卷 / 12期

关键词：

D O I：

10.1200/JCO.2004.03.918

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

引用

页码：2270 / 2272

页数：3

共 16 条

[1] Randomized phase II study of multiple dose levels of CCI-779, a novel mammalian target of rapamycin kinase inhibitor, in patients with advanced refractory renal cell carcinoma [J].

Atkins, MB ;

Hidalgo, M ;

Stadler, WM ;

Logan, TF ;

Dutcher, JP ;

Hudes, GR ;

Park, Y ;

Lion, SH ;

Marshall, B ;

Boni, JP ;

Dukart, G ;

Sherman, ML .

JOURNAL OF CLINICAL ONCOLOGY, 2004, 22 (05) :909-918

[2] Antitumor efficacy of intermittent treatment schedules with the rapamycin derivative RAD001 correlates with prolonged inactivation of ribosomal protein S6 kinase 1 in peripheral blood mononuclear cells [J].

Boulay, A ;

Zumstein-Mecker, S ;

Stephan, C ;

Beuvink, I ;

Zilbermann, F ;

Haller, R ;

Tobler, S ;

Heusser, C ;

O'Reilly, T ;

Stolz, B ;

Marti, A ;

Thomas, G ;

Lane, HA .

CANCER RESEARCH, 2004, 64 (01) :252-261

[3] Clinical development of mammalian target of rapamycin inhibitors [J].

Dancey, JE .

HEMATOLOGY-ONCOLOGY CLINICS OF NORTH AMERICA, 2002, 16 (05) :1101-+

[4]

Dudkin L, 2001, CLIN CANCER RES, V7, P1758

[5] The rapamycin-sensitive signal transduction pathway as a target for cancer therapy [J].

Hidalgo, M ;

Rowinsky, EK .

ONCOGENE, 2000, 19 (56) :6680-6686

[6] Rapamycins - Mechanism of action and cellular resistance [J].

Huang, SL ;

Bjornsti, MA ;

Houghton, PJ .

CANCER BIOLOGY & THERAPY, 2003, 2 (03) :222-232

[7]

Mita Monica M, 2003, Clin Breast Cancer, V4, P126, DOI 10.3816/CBC.2003.n.018

[8] Enhanced sensitivity of PTEN-deficient tumors to inhibition of FRAP/mTOR [J].

Neshat, MS ;

Mellinghoff, IK ;

Tran, C ;

Stiles, B ;

Thomas, G ;

Petersen, R ;

Frost, P ;

Gibbons, JJ ;

Wu, H ;

Sawyers, CL .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2001, 98 (18) :10314-10319

[9] Determinants of rapamycin sensitivity in breast cancer cells [J].

Noh, WC ;

Mondesire, WH ;

Peng, JY ;

Jian, WG ;

Zhang, HX ;

Dong, JJ ;

Mills, GB ;

Hung, MC ;

Meric-Bernstam, F .

CLINICAL CANCER RESEARCH, 2004, 10 (03) :1013-1023

[10]

Peralba JM, 2003, CLIN CANCER RES, V9, P2887

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