Treatment of mammary and extramammary Paget's skin disease with topical imiquimod

被引：39

作者：

Mirer, Ewa ^{[1
]}

El Sayed, Fouad ^{[1
]}

Ammoury, Alfred ^{[1
]}

Lamant, Laurence ^{[1
]}

Messer, Line ^{[1
]}

Bazex, Jacques ^{[1
]}

机构：

[1] CHU Purpan, Dept Dermatol, F-31059 Toulouse 09, France

来源：

JOURNAL OF DERMATOLOGICAL TREATMENT | 2006年 / 17卷 / 03期

关键词：

Aldara; extramammary Paget's disease; imiquimod; mammary Paget's disease; skin cancer; topical treatment;

D O I：

10.1080/09546630600788877

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

Background: Paget's disease is an uncommon epidermal cancer, affecting all skin regions wherever apocrine glands are present. It is divided into extramammary (EMPD) and mammary Paget's disease (MPD). It can be confined to the epithelium or may be associated with an underlying adenocarcinoma. The diagnosis is confirmed by skin biopsy and the treatment depends on characteristics of the underlying cancer. Surgery is the first-line treatment. Imiquimod, a topical immunomodulator, approved its efficiency in several skin neoplasms and has been shown as a safe treatment for EMPD. However, it has never been reported for the treatment of MPD. Observations: We report on two cases of EMPD and MPD successfully treated with imiquimod 5% cream. Conclusion: This non-surgical method may be considered as a primary treatment when Paget's disease is not associated with an underlying malignancy. The good prognosis with a long-term survival, the anatomic localization and the poor general condition of elderly people may favor imiquimod as an alternative treatment. On the other hand, it will reduce the extent of excision when it anticipates surgery.

引用

页码：167 / 171

页数：5

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