Graphene oxide-DNA based sensors

被引：168

作者：

Gao, Li ^{[1
]}

Lian, Chaoqun ^{[2
]}

Zhou, Yang ^{[1
]}

Yan, Lirong ^{[3
]}

Li, Qin ^{[1
]}

Zhang, Chunxia ^{[1
]}

Chen, Liang ^{[1
]}

Chen, Keping ^{[1
]}

机构：

[1] Jiangsu Univ, Inst Life Sci, Zhenjiang 212013, Peoples R China

[2] Jiangsu Univ, Sch Food & Biol Engn, Zhenjiang 212013, Peoples R China

[3] Jiangsu Univ, Affiliated Hosp, Dept Gerontol, Zhenjiang 212001, Peoples R China

来源：

BIOSENSORS & BIOELECTRONICS | 2014年 / 60卷

基金：

中国国家自然科学基金;

关键词：

DNA-based sensors; Electrochemical sensors; FRET; Graphene oxide; RESONANCE ENERGY-TRANSFER; LABEL-FREE ASSAY; FUNCTIONALIZED GRAPHENE; GOLD NANOPARTICLES; FLUORESCENCE DETECTION; SIGNAL AMPLIFICATION; EXONUCLEASE ACTIVITY; SENSITIVE DETECTION; CYSTEINE DETECTION; LOGIC GATE;

D O I：

10.1016/j.bios.2014.03.039

中图分类号：

Q6 [生物物理学];

学科分类号：

071011 ;

摘要：

Since graphene oxide (GO) is readily available and exhibits exceptional optical, electrical, mechanical and chemical properties, it has attracted increasing interests for use in GO-DNA based sensors. This paper reviews the advances in GO-DNA based sensors using DNA as recognition elements. In solution, GO is as an excellent acceptor of fluorescence resonance energy transfer (FRET) to quench the fluorescence in dye labeled DNA sequences. This review discusses the emerging GO-DNA based sensors related to FRET for use in the detection of DNA, proteins, metal ions, cysteine (Cys), and others. The application of the electrochemical GO-DNA based sensors is also summarized because GO possesses exceptional electrochemical properties. The detection mechanisms and the advantages of GO are also revealed and discussed. GO-DNA based sensors perform well at low cost and high sensitivity, and provide low detection limits. Additionally, GO-DNA based sensors should appear in the near future as scientists explore their usefulness and properties. Finally, future perspectives and possible challenges in this area are outlined. (C) 2014 Elsevier B.V. All rights reserved.

引用

页码：22 / 29

页数：8

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