Development of cancer immunotherapies based on identification of the genes encoding cancer regression antigens

被引：115

作者：

Rosenberg, SA

机构：

[1] Surgery Branch, Division of Clinical Sciences, National Cancer Institute, Bethesda, MD

[2] National Institutes of Health, Bldg. 10, Bethesda

来源：

JOURNAL OF THE NATIONAL CANCER INSTITUTE | 1996年 / 88卷 / 22期

关键词：

D O I：

10.1093/jnci/88.22.1635

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Tumor-infiltrating lymphocytes (TILs) have been grown from patients with metastatic melanoma and administered to the autologous patients to identify those TIL populations capable of mediating tumor regression. These TILs have been used to clone the genes that encode melanoma antigens. With the use of this strategy, we have identified six different genes encoding antigens restricted by multiple HLA alleles that appear to be related to tumor regression in patients. These antigens are now being used to develop immunization approaches for the treatment of patients with metastatic melanoma. The availability of genes encoding unique cancer antigens is opening new possibilities for the development of immunotherapies for the treatment of patients with cancer.

引用

页码：1635 / 1644

页数：10

共 63 条

[21] AUTOLOGOUS TUMOR-SPECIFIC CYTO-TOXIC LYMPHOCYTES-T IN THE INFILTRATE OF HUMAN METASTATIC MELANOMAS - ACTIVATION BY INTERLEUKIN-2 AND AUTOLOGOUS TUMOR-CELLS, AND INVOLVEMENT OF THE T-CELL RECEPTOR [J].