Aging and innate immunity in the mouse: impact of intrinsic and extrinsic factors

被引：128

作者：

Kovacs, Elizabeth J. ^{[1
]}

Palmer, Jessica L. ^{[1
]}

Fortin, Carl F. ^{[2
]}

Fueloep, Tamas, Jr. ^{[3
]}

Goldstein, Daniel R. ^{[4
]}

Linton, Phyllis-Jean ^{[5
]}

机构：

[1] Loyola Univ, Dept Cell Biol Neurobiol & Anat, Burn & Shock Trauma Inst, Dept Surg,Immunol & Aging Program,Med Ctr, Maywood, IL 60153 USA

[2] Univ Sherbrooke, Grad Program Immunol, Clin Res Ctr, Fac Med, Quebec City, PQ J1H 4C4, Canada

[3] Univ Sherbrooke, Immunol Lab, Res Ctr Aging, Quebec City, PQ J1H 4C4, Canada

[4] Yale Univ, Sect Cardiovasc Med, Dept Internal Med, New Haven, CT 06520 USA

[5] Sidney Kimmel Canc Ctr, San Diego, CA 92121 USA

来源：

TRENDS IN IMMUNOLOGY | 2009年 / 30卷 / 07期

基金：

加拿大健康研究院;

关键词：

PLASMACYTOID DENDRITIC CELLS; MACROPHAGE FUNCTION; AGED MICE; INFLAMMATORY RESPONSE; SIGNAL-TRANSDUCTION; SYSTEM; NEUTROPHILS; ACTIVATION; RECOGNITION; IMMUNOSENESCENCE;

D O I：

10.1016/j.it.2009.03.012

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Aging affects every innate immune cell, including changes in cell numbers and function. Defects in the function of some cells are intrinsic, whereas for other cells, defects are extrinsic and possibly the consequence of the complex interactions with other cell types or the environmental milieu that is altered with aging. Abnormal function contributes to worsened outcomes after injury or infection and leads to diseases observed in the elderly. Knowing the mechanisms responsible for the aberrant function of innate immune cells might lead to the development of therapeutic strategies designed to improve innate immunity in aged individuals. Herein, advances in the field of innate immunity and aging with a focus on neutrophils, macrophages and dendritic cells in laboratory animals are discussed.

引用

页码：319 / 324

页数：6

共 55 条

[1] Biology of dendritic cells in aging [J].

Agrawal, Anshu ;

Agrawal, Sudhanshu ;

Tay, Jia ;

Gupta, Sudhir .

JOURNAL OF CLINICAL IMMUNOLOGY, 2008, 28 (01) :14-20

[2] B cell development and receptor diversity during aging [J].

Allman, D ;

Miller, JP .

CURRENT OPINION IN IMMUNOLOGY, 2005, 17 (05) :463-467

[3] Type I interferon dependence of plasmacytoid dendritic cell activation and migration [J].

Asselin-Paturel, C ;

Brizard, G ;

Chemin, K ;

Boonstra, A ;

O'Garra, A ;

Vicari, A ;

Trinchieri, G .

JOURNAL OF EXPERIMENTAL MEDICINE, 2005, 201 (07) :1157-1167

[4] Age-dependent decrease in Toll-like receptor 4-mediated proinflammatory cytokine production and mitogen-activated protein kinase expression [J].

Boehmer, ED ;

Goral, J ;

Faunce, DE ;

Kovacs, EJ .

JOURNAL OF LEUKOCYTE BIOLOGY, 2004, 75 (02) :342-349

[5] Aging negatively skews macrophage TLR2- and TLR4-mediated pro-inflammatory responses without affecting the IL-2-stimulated pathway [J].

Boehmer, ED ;

Meehan, MJ ;

Cutro, BT ;

Kovacs, EJ .

MECHANISMS OF AGEING AND DEVELOPMENT, 2005, 126 (12) :1305-1313

[6] Molecular basis of age-associated cytokine dysregulation in LPS-stimulated macrophages [J].

Chelvarajan, R. Lakshman ;

Liu, Yushu ;

Popa, Diana ;

Getchell, Marilyn L. ;

Getchell, Thomas V. ;

Stromberg, Arnold J. ;

Bondada, Subbarao .

JOURNAL OF LEUKOCYTE BIOLOGY, 2006, 79 (06) :1314-1327

[7] The unresponsiveness of aged mice to polysaccharide antigens is a result of a defect in macrophage function [J].

Chelvarajan, RL ;

Collins, SM ;

Van Willigen, JM ;

Bondada, S .

JOURNAL OF LEUKOCYTE BIOLOGY, 2005, 77 (04) :503-512

[8] Autophagy and aging: keeping that old broom working [J].

Cuervo, Ana Maria .

TRENDS IN GENETICS, 2008, 24 (12) :604-612

[9] Genetic alterations in the ageing immune system: impact on infection and cancer [J].

Effros, RB .

MECHANISMS OF AGEING AND DEVELOPMENT, 2003, 124 (01) :71-77

[10] Aging and Neutrophils: There Is Still Much To Do [J].

Fortin, Carl F. ;

McDonald, Patrick P. ;

Lesur, Olivier ;

Fulop, Tamas, Jr. .

REJUVENATION RESEARCH, 2008, 11 (05) :873-882

← 1 2 3 4 5 6 →