Endothelin(B) (ET(B)) receptor-activated potentiation of cholinergic nerve-mediated contraction in human bronchus

被引：43

作者：

Fernandes, LB ^{[1
]}

Henry, PJ ^{[1
]}

Rigby, PJ ^{[1
]}

Goldie, RG ^{[1
]}

机构：

[1] UNIV WESTERN AUSTRALIA,DEPT PHARMACOL,NEDLANDS,WA 6907,AUSTRALIA

来源：

BRITISH JOURNAL OF PHARMACOLOGY | 1996年 / 118卷 / 08期

关键词：

endothelin receptors; cholinergic nerves; human bronchus; sarafotoxin S6c;

D O I：

10.1111/j.1476-5381.1996.tb15617.x

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

In human isolated bronchial preparations, the endothelin(B) (ET(B)) receptor-selective agonist, sarafotoxin S6c (Stx6c; 1 nM) increased nerve-mediated contraction in response to electrical field stimulation (EFS) at 0.5-1 Hz from 19 +/- 4% to 42 +/- 7% (n=9). This effect was blocked in the presence of the ET(B) receptor-selective antagonist, BQ-788 (10 mu M) These data are consistent with findings in some animal species that ET-1 and related peptides have marked neuromodulatory influences on the cholinergic system. Furthermore, they provide additional support for the concept that ET-1 may have a mediator role in bronchial obstruction in asthma.

引用

页码：1873 / 1874

页数：2

共 9 条

[1]

BLACK JL, 1995, AM J RESP CRIT CARE, V151, pA824

[2] ROLE OF CYSTEINYL-LEUKOTRIENES AND HISTAMINE IN MEDIATING INTRINSIC TONE IN ISOLATED HUMAN BRONCHI [J].

ELLIS, JL ;

UNDEM, BJ .

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 1994, 149 (01) :118-122

[3] ENDOTHELIN-1 RECEPTOR DENSITY, DISTRIBUTION, AND FUNCTION IN HUMAN ISOLATED ASTHMATIC AIRWAYS [J].

GOLDIE, RG ;

HENRY, PJ ;

KNOTT, PG ;

SELF, GJ ;

LUTTMANN, MA ;

HAY, DWP .

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 1995, 152 (05) :1653-1658

[4] ENDOTHELIN AND THE RESPIRATORY SYSTEM [J].

HAY, DWP ;

HENRY, PJ ;

GOLDIE, RG .

TRENDS IN PHARMACOLOGICAL SCIENCES, 1993, 14 (01) :29-31

[5] RELATIONSHIP BETWEEN ENDOTHELIN-1 BINDING-SITE DENSITIES AND CONSTRICTOR ACTIVITIES IN HUMAN AND ANIMAL AIRWAY SMOOTH-MUSCLE [J].

HENRY, PJ ;

RIGBY, PJ ;

SELF, GJ ;

PREUSS, JM ;

GOLDIE, RG .

BRITISH JOURNAL OF PHARMACOLOGY, 1990, 100 (04) :786-792

[6] Inhibition by endothelin-1 of cholinergic nerve-mediated acetylcholine release and contraction in sheep isolated trachea [J].

Henry, PJ ;

Shen, A ;

Mitchelson, F ;

Goldie, RG .

BRITISH JOURNAL OF PHARMACOLOGY, 1996, 118 (03) :762-768

[7] POTENTIATION BY ENDOTHELIN-1 OF CHOLINERGIC NERVE-MEDIATED CONTRACTIONS IN MOUSE TRACHEA VIA ACTIVATION OF ET(B) RECEPTORS [J].

HENRY, PJ ;

GOLDIE, RG .

BRITISH JOURNAL OF PHARMACOLOGY, 1995, 114 (03) :563-569

[8] ENDOTHELIN-3 INCREASES TRANSMISSION IN THE RABBIT PULMONARY PARASYMPATHETIC NERVOUS-SYSTEM [J].

MCKAY, KO ;

ARMOUR, CL ;

BLACK, JL .

JOURNAL OF CARDIOVASCULAR PHARMACOLOGY, 1993, 22 :S181-S184

[9] ENDOTHELIN IMMUNOREACTIVITY OF AIRWAY EPITHELIUM IN ASTHMATIC-PATIENTS [J].

SPRINGALL, DR ;

HOWARTH, PH ;

COUNIHAN, H ;

DJUKANOVIC, R ;

HOLGATE, ST ;

POLAK, JM .

LANCET, 1991, 337 (8743) :697-701

← 1 →