De novo synthesis of the enantiomers Ins(1,2,3,4)P4 and Ins(1,2,3,6)P4 -: regiospecificity of their enzymatic dephosphorylation

被引：24

作者：

Plettenburg, O ^{[1
]}

Adelt, S ^{[1
]}

Vogel, G ^{[1
]}

Altenbach, HJ ^{[1
]}

机构：

[1] Berg Univ Gesamthsch Wuppertal, Inst Organ Chem & Biochem, D-42097 Wuppertal, Germany

来源：

TETRAHEDRON-ASYMMETRY | 2000年 / 11卷 / 05期

关键词：

D O I：

10.1016/S0957-4166(00)00063-X

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

(T)he first total synthesis of Ins(1,2,3,4)P-4 and Ins(1,2,3,6)P-4 is presented. Starting from p-benzoquinone, we took advantage of the C-2-symmetry of conduritol-B intermediates. The target compounds were dephosphorylated by several enzymes, and the resulting InsP(3) isomers, were identified. Some of these enzymatic conversions were found to be preparatively applicable and to allow the synthesis of Ins(1,2,3)P-3, Ins(2,3,6)P-3 and Ins(1,2,4)P-3. (C) 2000 Elsevier Science Ltd. All rights reserved.

引用

页码：1057 / 1061

页数：5

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