Drug-mediated toxicity caused by genetic deficiency of UDP-glucuronosyltransferases

被引：70

作者：

Burchell, B ^{[1
]}

Soars, M ^{[1
]}

Monaghan, G ^{[1
]}

Cassidy, A ^{[1
]}

Smith, D ^{[1
]}

Ethell, B ^{[1
]}

机构：

[1] Univ Dundee, Ninewells Med Sch, Dept Mol & Cellular Pathol, Dundee DD1 9SY, Scotland

来源：

TOXICOLOGY LETTERS | 2000年 / 112卷

关键词：

glucuronidation; bilirubin; anti-cancer agents;

D O I：

10.1016/S0378-4274(99)00209-X

中图分类号：

R99 [毒物学（毒理学）];

学科分类号：

100405 ;

摘要：

Human gene families encoding UDP-Glucuronosyltransferases (UGTs) have been identified and partially characterised. This family of enzymes catalysed the glucuronidation of drugs, xenobiotics and endobiotics. Genetic mutations and polymorphisms have been identified in several UGT genes and examples should be anticipated in all UGT genes. A common genetic defect in the TATA box promoter of the UGT1A1 gene is associated with Gilbert's Syndrome (GS) causing mild hyperbilirubinaemia. Recently, adverse effects of anticancer agents have been observed in Gilbert's patients due to reduced drug or bilirubin glucuronidation. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：333 / 340

页数：8