Hemoadsorption in critical care

被引:11
作者
Ikeda, T [1 ]
机构
[1] Tokyo Med Univ, Hachiouji Med Ctr, Div Crit Care & Emergency Med, Tokyo 1930998, Japan
来源
THERAPEUTIC APHERESIS | 2002年 / 6卷 / 03期
关键词
cytokine; endotoxin; hemoadsorption; plasminogen activator inhibitor-1;
D O I
10.1046/j.1526-0968.2002.00430.x
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
This paper concerns the results of endotoxin hemoadsorption therapy using a PMX column in patients with perforative peritonitis complicated by multiple organ failure. The subjects were 31 patients aged 68 12 years. When systolic arterial pressure decreased to less than 90 mm Hg, endotoxin hemoadsorption was initiated and continued for 2 h. At the completion of endotoxin hemoadsorption, systolic arterial pressure, diastolic arterial pressure, and mean arterial pressure were significantly increased. Platelet count decreased to less than 50,000/mm(3) in 30% of patients. As for cytokines and vascular endothelial cell function markers, interleukin-6 and plasminogen activator inhibitor-1 significantly decreased. These results suggest favorable effects of endotoxin hemoadsorption on the hemodynamic and pathophysiological conditions in patients with septic shock although attention should be given to the decrease in platelet count.
引用
收藏
页码:189 / 192
页数:4
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