Sulfur-controlled 5-exo selective aryl radical cyclisation of N-vinylic 2-bromobenzamides: Synthesis of lennoxamine and chilenine

被引：55

作者：

Ishibashi, H ^{[1
]}

Kawanami, H ^{[1
]}

Ikeda, M ^{[1
]}

机构：

[1] KYOTO PHARMACEUT UNIV,KYOTO 607,JAPAN

来源：

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1 | 1997年 / 06期

关键词：

D O I：

10.1039/a606723i

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Bu(3)SnH-mediated aryl radical cyclisation of N-[2,2-bis(phenylsulfanyl)ethenyl]-2-bromobenzamides 12a-d and 16 takes place in a 5-exo manner to give exclusively the isoindolones 15a-d and 17, respectively. The isoindolone 17 is converted into lennoxamine and a key intermediate 20 for the synthesis of chilenine.

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页码：817 / 821

页数：5

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