Luteinizing hormone deficiency and female infertility in mice lacking the transcription factor NGFI-A (Egr-1)

被引：427

作者：

Lee, SL

Sadovsky, Y

Swirnoff, AH

Polish, JA

Goda, P

Gavrilina, G

Milbrandt, J

机构：

[1] WASHINGTON UNIV,SCH MED,DEPT PATHOL,ST LOUIS,MO 63110

[2] WASHINGTON UNIV,SCH MED,DEPT INTERNAL MED,ST LOUIS,MO 63110

[3] WASHINGTON UNIV,SCH MED,DEPT OBSTET & GYNECOL,ST LOUIS,MO 63110

来源：

SCIENCE | 1996年 / 273卷 / 5279期

关键词：

D O I：

10.1126/science.273.5279.1219

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The immediate-early transcription factor NGFl-A (also called Egr-1, zif/268, or Krox-24) is thought to couple extracellular signals to changes in gene expression, Although activins and inhibins regulate follicle-stimulating hormone (FSH) synthesis, no factor has been identified that exclusively regulates luteinizing hormone (LH) synthesis. An analysis of NGFl-A-deficient mice derived from embryonic stem cells demonstrated female infertility that was secondary to LH-beta deficiency. Ovariectomy led to increased amounts of FSH-beta but not LH-beta messenger RNA, which suggested a pituitary defect. A conserved, canonical NGFl-A site in the LH-beta promoter was required for synergistic activation by NGFl-A and steroidogenic factor-1 (SF-1). NGFl-A apparently influences female reproductive capacity through its regulation of LH-beta transcription.

引用

页码：1219 / 1221

页数：3

共 31 条

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