Reperfusion following focal cerebral ischemia alters distribution of neuronal cells with DNA fragmentation in mice

被引：53

作者：

Murakami, K

Kondo, T

Chan, PH

机构：

[1] UNIV CALIF SAN FRANCISCO,SCH MED,DEPT NEUROL SURG,CNS,INJURY & EDEMA RES CTR,SAN FRANCISCO,CA 94143

[2] UNIV CALIF SAN FRANCISCO,SCH MED,DEPT NEUROL,CNS,INJURY & EDEMA RES CTR,SAN FRANCISCO,CA 94143

来源：

BRAIN RESEARCH | 1997年 / 751卷 / 01期

关键词：

focal cerebral ischemia; reperfusion injury; DNA fragmentation; TUNEL staining;

D O I：

10.1016/S0006-8993(97)00029-2

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

To clarify the role of reperfusion in DNA damage following focal cerebral ischemia, we determined the distribution of cells with DNA fragmentation following permanent or transient focal ischemia. Less DNA-damaged cells were observed in the permanent than in the transient group in the ischemic core, but there was no difference in the boundary zone. We conclude that reperfusion following transient ischemia may exacerbate neuronal death following DNA damage.

引用

页码：160 / 164

页数：5

共 18 条

[11] GLOBAL-ISCHEMIA CAN CAUSE DNA FRAGMENTATION INDICATIVE OF APOPTOSIS IN RAT-BRAIN [J].