Influence of thyroid volume reduction on calculated dose in radioiodine therapy of Graves' hyperthyroidism

被引:29
作者
Traino, AC
Di Martino, F
Lazzeri, M
Stabin, MG
机构
[1] Osped S Chiara, Serv Fis Sanitaria, I-56100 Pisa, Italy
[2] Univ Fed Pernambuco, Dept Nucl Energy, BR-50740540 Recife, PE, Brazil
关键词
D O I
10.1088/0031-9155/45/1/309
中图分类号
R318 [生物医学工程];
学科分类号
0831 ;
摘要
Administration of radioactive iodine (I-131) is an effective treatment for hyperthyroidism due to Graves' disease. Recently several investigators have shown that the success of this therapy may depend on the absorbed dose to the thyroid. Thyroid dose varies inversely with the mass of the gland. Much experimental evidence demonstrates that a reduction of the thyroid volume (mass) may occur after radioiodine therapy. In this work we evaluate the influence of the volume reduction on the calculation of the absorbed dose to the thyroid. A mathematical model of thyroid mass reduction after I-131 therapy is presented, based on masses evaluated with ultrasonography of ten patients treated in the endocrinology department of our hospital. This model was applied to the general formula for calculation of the thyroid doses in these patients. The dose values obtained considering a reduction of thyroid mass after the treatment are often quite different from those obtained without considering change in mass (from 9% to 30% greater). We conclude that the consideration of thyroid mass reduction is important for an accurate estimation of the calculated dose.
引用
收藏
页码:121 / 129
页数:9
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