Hyaluronic acid-based biopharmaceutical delivery and tumor-targeted drug delivery system

被引：279

作者：

Huang, Gangliang ^{[1
]}

Huang, Hualiang ^{[2
]}

机构：

[1] Chongqing Normal Univ, Act Carbohydrate Res Inst, Chongqing 401331, Peoples R China

[2] Wuhan Inst Technol, Sch Chem & Environm Engn, Wuhan 430073, Hubei, Peoples R China

来源：

JOURNAL OF CONTROLLED RELEASE | 2018年 / 278卷

关键词：

Hyaluronic acid; Carrier; Sustained release; Biopharmaceutical delivery; Tumor-targeted drug delivery; RELEASE FORMULATION; PACLITAXEL DELIVERY; SUSTAINED-RELEASE; NANOPARTICLES; SIRNA; CONJUGATE; LIPOSOMES; LUNG; DERIVATIVES; RESISTANCE;

D O I：

10.1016/j.jconrel.2018.04.015

中图分类号：

O6 [化学];

学科分类号：

070301 [无机化学];

摘要：

Hyaluronic acid (HA) is a natural polysaccharide with good biocompatibility and degradability. HA and its derivatives can be used as sustained-release carriers for drugs, which can delay the release of drugs and have a long-acting effect. They can be used for the delivery of various drugs such as proteins, nucleic acids and antitumor drugs. HA and its derivatives can specifically bind to multiple receptors on the cell surface and can be used for targeted drug delivery, especially for the delivery of anti-tumor drugs. Thus, there are different forms of tumor-targeted drug delivery systems based on HA.

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页码：122 / 126

页数：5

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