Vagus nerve stimulation therapy for epilepsy in older adults

被引：55

作者：

Sirven, JI

Sperling, M

Naritoku, D

Schachter, S

Labar, D

Holmes, M

Wilensky, A

Cibula, J

Labiner, DM

Bergen, D

Ristanovic, R

Harvey, J

Dasheiff, R

Morris, GL

O'Donovan, CA

Ojemann, L

Scales, D

Nadkarni, M

Richards, B

Sanchez, JD

机构：

[1] Mayo Clin, Dept Neurol, Scottsdale, AZ 85269 USA

[2] Thomas Jefferson Univ, Jefferson Med Coll, Philadelphia, PA 19107 USA

[3] So Illinois Univ, Springfield, IL USA

[4] Harvard Univ, Sch Med, Boston, MA USA

[5] Cornell Med Sch, New York, NY USA

[6] Univ Washington, Seattle, WA 98195 USA

[7] Univ Kentucky, Lexington, KY 40506 USA

[8] Univ Arizona, Tucson, AZ USA

[9] Rush Univ, Chicago, IL 60612 USA

[10] Neurol Clin Texas, Dallas, TX USA

[11] New Jersey Neurosci Inst, Edison, NJ USA

[12] Univ Oklahoma, Oklahoma City, OK USA

[13] Med Coll Wisconsin, Madison, WI USA

[14] Wake Forest Univ, Winston Salem, NC 27109 USA

[15] Jacksonville Neurol Clin, Jacksonville, FL USA

[16] Univ Florida, Gainesville, FL USA

[17] Univ S Dakota, Sioux Falls, SD USA

来源：

NEUROLOGY | 2000年 / 54卷 / 05期

关键词：

seizures; epilepsy; vagus nerve stimulation; elderly;

D O I：

10.1212/WNL.54.5.1179

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The authors assessed the efficacy, safety, and tolerability of vagus nerve stimulation (VNS) for refractory epilepsy in 45 adults 50 years of age and older. They determined seizure frequency, adverse effects, and quality of life. At 3 months, 12 patients had a >50% decrease in seizure frequency; at 1 year, 21 of 31 studied individuals had a >50% seizure decrease. Side effects were mild and transient. Quality of life scores improved significantly with time.

引用

页码：1179 / 1182

页数：4

共 9 条

[1] Evaluation of refractory epilepsy treated with vagus nerve stimulation for up to 5 years [J].

Ben-Menachem, E ;

Hellström, K ;

Waldton, C ;

Augustinsson, LE .

NEUROLOGY, 1999, 52 (06) :1265-1267

[2]

DeGiorgio C, 1999, NEUROLOGY, V52, pA109

[3] A RANDOMIZED CONTROLLED TRIAL OF CHRONIC VAGUS NERVE-STIMULATION FOR TREATMENT OF MEDICALLY INTRACTABLE SEIZURES [J].

GEORGE, R ;

SONNEN, A ;

UPTON, A ;

SALINSKY, M ;

RISTANOVIC, R ;

BERGEN, D ;

MIRZA, W ;

ROSENFELD, W ;

NARITOKU, D ;

MANONESPAILLAT, R ;

BAROLAT, G ;

WILLIS, J ;

STEFAN, H ;

TREIG, T ;

HUFNAGEL, A ;

KUZNIECKY, R ;

UTHMAN, B ;

WILDER, BJ ;

AUGUSTINSSON, L ;

BENMENACHEM, E ;

RAMSAY, E ;

WERNICKE, JF ;

TARVER, WB .

NEUROLOGY, 1995, 45 (02) :224-230

[4] Vagus nerve stimulation therapy for partial-onset seizures - A randomized active-control trial [J].

Handforth, A ;

DeGiorgio, CM ;

Schachter, SC ;

Uthman, BM ;

Naritoku, DK ;

Tecoma, ES ;

Henry, TR ;

Collins, SD ;

Vaughn, BV ;

Gilmartin, RC ;

Labar, DR ;

Morris, GL ;

Salinsky, MC ;

Osorio, I ;

Ristanovic, RK ;

Labiner, DM ;

Jones, JC ;

Murphy, JV ;

Ney, GC ;

Wheless, JW .

NEUROLOGY, 1998, 51 (01) :48-55

[5] Acute blood flow changes and efficacy of vagus nerve stimulation in partial epilepsy [J].

Henry, TR ;

Votaw, JR ;

Pennell, PB ;

Epstein, CM ;

Bakay, RAE ;

Faber, TL ;

Grafton, ST ;

Hoffman, JM .

NEUROLOGY, 1999, 52 (06) :1166-1173

[6] Locus coeruleus lesions suppress the seizure-attenuating effects of vagus nerve stimulation [J].

Krahl, SE ;

Clark, KB ;

Smith, DC ;

Browning, RA .

EPILEPSIA, 1998, 39 (07) :709-714

[7] Vagus nerve stimulation [J].

Schachter, SC ;

Saper, CB .

EPILEPSIA, 1998, 39 (07) :677-686

[8] Ventricular asystole during vagus nerve stimulation for epilepsy in humans [J].

Tatum, WO ;

Moore, DB ;

Stecker, MM ;

Baltuch, GH ;

French, JA ;

Ferreira, JA ;

Carney, PM ;

Labar, DR ;

Vale, FL .

NEUROLOGY, 1999, 52 (06) :1267-1269

[9]

Tecoma ES, 1999, NEUROLOGY, V52, pA239

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