R-spondin1 tips the balance in sex determination

被引：35

作者：

Capel, Blanche ^{[1
]}

机构：

[1] Duke Univ, Med Ctr, Dept Cell Biol, Durham, NC 27710 USA

来源：

NATURE GENETICS | 2006年 / 38卷 / 11期

关键词：

D O I：

10.1038/ng1106-1233

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Female-to-male sex reversal is an extremely rare and puzzling phenomenon. A new study identifies mutations in the gene encoding R-spondin1 in XX sex-reversed individuals and suggests that antagonistic pathways in the bipotential gonad regulate sex determination.

引用

页码：1233 / 1234

页数：3

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