Human herpesvirus 8 and Epstein Barr-Virus in a cutaneons B-cell lymphoma and a malignant cell line established from the blood of an AIDS patient

被引：28

作者：

Morand, P ^{[1
]}

Buisson, M ^{[1
]}

Collandre, H ^{[1
]}

Chanzy, B ^{[1
]}

Genoulaz, O ^{[1
]}

Bourgeat, MJ ^{[1
]}

Pinel, N ^{[1
]}

Leclercq, P ^{[1
]}

Leroux, D ^{[1
]}

Marechal, V ^{[1
]}

Fritsch, L ^{[1
]}

Ruigrok, R ^{[1
]}

Seigneurin, JM ^{[1
]}

机构：

[1] CHU Grenoble, Fac Med, Lab Virol Med Mol, F-38043 Grenoble, France

来源：

LEUKEMIA & LYMPHOMA | 1999年 / 35卷 / 3-4期

关键词：

human herpesvirus 8; Epstein-Barr virus; lymphoma; cell line;

D O I：

10.3109/10428199909145743

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Human Herpesvirus 8 (HHV-8) has been consistently associated with Primary Effusion Lymphoma (PEL or body-cavity-based lymphoma) but not with other lymphomas, This paper reports on an AIDS patient without obvious malignant effusion in body cavities but with a cutaneous lymphoma where HHV-8 and Epstein-Barr virus (EBV) were detected by PCR and electron microscopy, Both viruses were also detected in all the cells of a malignant cell line (BBG1) established from the patient's peripheral blood mononuclear cells. As in PEL and PEL-derived cell lines, both the tumor and the Lines lacked B-antigen expression in immunological studies but were of the same B origin as shown by clonal immunoglobulin gene rearrangements. In contrast to other co-infected cell lines, BBG1 and subclones spontaneously expressed the HHV-8 lytic antigens p40, p27, p60 and the EBV transforming latent antigen EBNA2. These data suggest that the clinical and biological features of HHV-8-and EBV-associated lymphomas could be wider than has been described to date in PEL particularly with the in vivo presence of circulating malignant dually-infected cells engaged in a spontaneous HHV-8 lytic infection.

引用

页码：379 / 387

页数：9

共 36 条

[21] Epstein-Barr virus latent gene expression in primary effusion lymphomas containing Kaposi's sarcoma-associated herpesvirus human herpesvirus-8 [J].

Horenstein, MG ;

Nador, RG ;

Chadburn, A ;

Hyjek, EM ;

Inghirami, G ;

Knowles, DM ;

Cesarman, E .

BLOOD, 1997, 90 (03) :1186-1191

[22] Human herpesvirus 8 (HHV-8) in the pathogenesis of Kaposi's sarcoma and other diseases [J].

Humphrey, RW ;

Davis, DA ;

Newcomb, FM ;

Yarchoan, R .

LEUKEMIA & LYMPHOMA, 1998, 28 (3-4) :255-264

[23] T-CELL DEATH BY APOPTOSIS IN VERTICALLY HUMAN IMMUNODEFICIENCY VIRUS-INFECTED CHILDREN COINCIDES WITH EXPANSION OF CD8(+) INTERLEUKIN-2-RECEPTOR(-) HLA-DR(+) T-CELLS - SIGN OF A POSSIBLE ROLE FOR HERPES VIRUSES AS COFACTORS [J].

LAUENER, RP ;

HUTTNER, S ;

BUISSON, M ;

HOSSLE, JP ;

ALBISETTI, M ;

SEIGNEURIN, JM ;

SEGER, RA ;

NADAL, D .

BLOOD, 1995, 86 (04) :1400-1407

[24] Antibodies to butyrate-inducible antigens of Kaposi's sarcoma-associated herpesvirus in patients with HIV-1 infection [J].

Miller, G ;

Rigsby, MO ;

Heston, L ;

Grogan, E ;

Sun, R ;

Metroka, C ;

Levy, JA ;

Gao, SJ ;

Chang, Y ;

Moore, P .

NEW ENGLAND JOURNAL OF MEDICINE, 1996, 334 (20) :1292-1297

[25] Selective switch between latency and lytic replication of Kaposi's sarcoma herpesvirus and Epstein-Barr virus in dually infected body cavity lymphoma cells [J].

Miller, G ;

Heston, L ;

Grogan, E ;

Gradoville, L ;

Rigsby, M ;

Sun, R ;

Shedd, D ;

Kushnaryov, VM ;

Grossberg, S ;

Chang, Y .

JOURNAL OF VIROLOGY, 1997, 71 (01) :314-324

[26] Primary characterization of a herpesvirus agent associated with Kaposi's sarcoma [J].

Moore, PS ;

Gao, SJ ;

Dominguez, G ;

Cesarman, E ;

Lungu, O ;

Knowles, DM ;

Garber, R ;

Pellett, PE ;

McGeoch, DJ ;

Chang, Y .

JOURNAL OF VIROLOGY, 1996, 70 (01) :549-558

[27] Primary effusion lymphoma: A distinct clinicopathologic entity associated with the Kaposi's sarcoma-associated herpes virus [J].

Nador, RG ;

Cesarman, E ;

Chadburn, A ;

Dawson, DB ;

Ansari, MQ ;

Said, J ;

Knowles, DM .

BLOOD, 1996, 88 (02) :645-656

[28] The 222- to 234-kilodalton latent nuclear protein (LNA) of Kaposi's sarcoma-associated herpesvirus (human herpesvirus 8) is encoded by orf73 and is a component of the latency-associated nuclear antigen [J].

Rainbow, L ;

Platt, GM ;

Simpson, GR ;

Sarid, R ;

Gao, SJ ;

Stoiber, H ;

Herrington, CS ;

Moore, PS ;

Schulz, TF .

JOURNAL OF VIROLOGY, 1997, 71 (08) :5915-5921

[29] Limited transmission of Kaposi's sarcoma-associated herpesvirus in cultured cells [J].

Renne, R ;

Blackbourn, D ;

Whitby, D ;

Levy, J ;

Ganem, D .

JOURNAL OF VIROLOGY, 1998, 72 (06) :5182-5188

[30] Lytic growth of Kaposi's sarcoma-associated herpesvirus (human herpesvirus 8) in culture [J].

Renne, R ;

Zhong, WD ;

Herndier, B ;

McGrath, M ;

Abbey, N ;

Kedes, D ;

Ganem, D .

NATURE MEDICINE, 1996, 2 (03) :342-346

← 1 2 3 4 →