Association of Irisin with Fat Mass, Resting Energy Expenditure, and Daily Activity in Conditions of Extreme Body Mass Index

被引：177

作者：

Pardo, Maria ^{[1
,2
,3
,4
]}

Crujeiras, Ana B. ^{[1
,2
,3
,5
]}

Amil, Maria ^{[1
,2
,3
]}

Aguera, Zaida ^{[3
,6
]}

Jimenez-Murcia, Susana ^{[3
,6
,7
]}

Banos, Rosa ^{[3
,8
]}

Botella, Cristina ^{[3
,9
]}

de la Torre, Rafael ^{[3
,10
]}

Estivill, Xavier ^{[11
,12
]}

Fagundo, Ana B. ^{[3
,6
]}

Fernandez-Real, Jose M. ^{[3
,13
]}

Fernandez-Garcia, Jose C. ^{[3
,14
]}

Fruhbeck, Gema ^{[3
,15
]}

Gomez-Ambrosi, Javier ^{[3
,15
]}

Rodriguez, Roser ^{[3
,13
]}

Tinahones, Francisco J. ^{[3
,14
]}

Fernandez-Aranda, Fernando ^{[3
,6
,7
]}

Casanueva, Felipe F. ^{[1
,2
,3
]}

机构：

[1] Univ Hosp Santiago, XXIS SERGAS, Hlth Res Inst Santiago IDIS, Lab Mol & Cellular Endocrinol, Santiago De Compostela 15706, Spain

[2] Univ Santiago de Compostela, Santiago De Compostela 15706, Spain

[3] CIBER Fisiopatol Obesidad & Nutr CIBERobn, Santiago De Compostela 15706, Spain

[4] Univ Hosp Santiago, XXIS SERGAS, Hlth Res Inst Santiago IDIS, Obesid Grp,Lab 3, Santiago De Compostela 15706, Spain

[5] IDIBELL, PEBC, Bellvitge Biomed Res Inst, Canc Epigenet & Biol Program, Barcelona 08908, Spain

[6] Univ Hosp Bellvitge, IDIBELL, Dept Psychiat, Barcelona 08907, Spain

[7] Univ Barcelona, Sch Med, Dept Clin Sci, E-08007 Barcelona, Spain

[8] Univ Valencia, Dept Psychol Personal Evaluat & Treatment, Valencia 46010, Spain

[9] Jaume 1 Univ, Dept Basic Psychol Clin & Psychobiol, Castellon de La Plana 12071, Spain

[10] Hosp Mar, IMIM, Res Inst, Human Pharmacol & Clin Neurosci Res Grp,Neurosci, Barcelona, Spain

[11] CRG, Barcelona 08003, Spain

[12] CIBERESP, Barcelona 08036, Spain

[13] Hosp Dr Josep Trueta, Inst Invest Biomed Girona IdlBGi, Dept Diabet Endocrinol & Nutr, Girona, Spain

[14] Univ Virgen Victoria, Hosp Cliin, Dept Diabet Endocrinol & Nutr, Malaga 29010, Spain

[15] Univ Navarra, Univ Navarra Clin, Dept Endocrinol & Nutr, Pamplona 31008, Spain

来源：

INTERNATIONAL JOURNAL OF ENDOCRINOLOGY | 2014年 / 2014卷

关键词：

WEIGHT-LOSS; CIRCULATING IRISIN; INSULIN-RESISTANCE; SKELETAL-MUSCLE; ADIPOSE-TISSUE; MESSENGER-RNA; OBESITY; EXERCISE; HUMANS; PLASMA;

D O I：

10.1155/2014/857270

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

FNDC5/irisin has been recently postulated as beneficial in the treatment of obesity and diabetes because it is induced in muscle by exercise, increasing energy expenditure. However, recent reports have shown that WAT also secretes irisin and that circulating irisin is elevated in obese subjects. The aim of this study was to evaluate irisin levels in conditions of extreme BMI and its correlation with basal metabolism and daily activity. The study involved 145 female patients, including 96 with extreme BMIs (30 anorexic (AN) and 66 obese (OB)) and 49 healthy normal weight (NW). The plasma irisin levels were significantly elevated in the OB patients compared with the AN and NW patients. Irisin also correlated positively with body weight, BMI, and fat mass. The OB patients exhibited the highest REE and higher daily physical activity compared with the AN patients but lower activity compared with the NW patients. The irisin levels were inversely correlated with daily physical activity and directly correlated with REE. Fat mass contributed to most of the variability of the irisin plasma levels independently of the other studied parameters. Conclusion. Irisin levels are influenced by energy expenditure independently of daily physical activity but fat mass is the main contributing factor.

引用

页数：9

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