From white to brown fat through the PGC-1α-dependent myokine irisin: implications for diabetes and obesity

被引:126
作者
Castillo-Quan, Jorge Ivan [1 ,2 ,3 ]
机构
[1] UCL, Inst Hlth Ageing, London WC1E 6BT, England
[2] UCL, Dept Genet Evolut & Environm, London WC1E 6BT, England
[3] UCL, Inst Neurol, Dept Mol Neurosci, London WC1N 3BG, England
关键词
ADIPOSE-TISSUE; ENERGY-METABOLISM; DISEASE; EXERCISE; AGONISTS; HUMANS; ALPHA; MICE;
D O I
10.1242/dmm.009894
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
引用
收藏
页码:293 / 295
页数:3
相关论文
共 18 条
[1]   A PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis [J].
Bostroem, Pontus ;
Wu, Jun ;
Jedrychowski, Mark P. ;
Korde, Anisha ;
Ye, Li ;
Lo, James C. ;
Rasbach, Kyle A. ;
Bostroem, Elisabeth Almer ;
Choi, Jang Hyun ;
Long, Jonathan Z. ;
Kajimura, Shingo ;
Zingaretti, Maria Cristina ;
Vind, Birgitte F. ;
Tu, Hua ;
Cinti, Saverio ;
Hojlund, Kurt ;
Gygi, Steven P. ;
Spiegelman, Bruce M. .
NATURE, 2012, 481 (7382) :463-U72
[2]   Parkin' control: regulation of PGC-1α through PARIS in Parkinson's disease [J].
Castillo-Quan, Jorge Ivan .
DISEASE MODELS & MECHANISMS, 2011, 4 (04) :427-429
[3]   Transcriptional repression of PGC-α by mutant huntingtin leads to mitochondrial dysfunction and neurodegeneration [J].
Cui, Libin ;
Jeong, Hyunkyung ;
Borovecki, Fran ;
Parkhurst, Christopher N. ;
Tanese, Naoko ;
Krainc, Dimitri .
CELL, 2006, 127 (01) :59-69
[4]   DIABETES Exercise and T2DM-move muscles more often! [J].
Dunstan, David .
NATURE REVIEWS ENDOCRINOLOGY, 2011, 7 (04) :189-190
[5]   PGC-1 coactivators: inducible regulators of energy metabolism in health and disease [J].
Finck, BN ;
Kelly, DP .
JOURNAL OF CLINICAL INVESTIGATION, 2006, 116 (03) :615-622
[6]   The role of exercise and PGC1α in inflammation and chronic disease [J].
Handschin, Christoph ;
Spiegelman, Bruce M. .
NATURE, 2008, 454 (7203) :463-469
[7]   PPARα: an emerging therapeutic target in diabetic microvascular damage [J].
Hiukka, Anne ;
Maranghi, Marianna ;
Matikainen, Niina ;
Taskinen, Marja-Riitta .
NATURE REVIEWS ENDOCRINOLOGY, 2010, 6 (08) :454-463
[8]  
Lichtenbelt WDV, 2009, NEW ENGL J MED, V360, P1500, DOI 10.1056/NEJMoa0808718
[9]   Brown adipose tissue-a new role in humans? [J].
Lidell, Martin E. ;
Enerback, Sven .
NATURE REVIEWS ENDOCRINOLOGY, 2010, 6 (06) :319-325
[10]   Defects in adaptive energy metabolism with CNS-Linked hyperactivity in PGC-1α null mice [J].
Lin, JD ;
Wu, PH ;
Tarr, PT ;
Lindenberg, KS ;
St-Pierre, J ;
Zhang, CY ;
Mootha, VK ;
Jäger, S ;
Vianna, CR ;
Reznick, RM ;
Cui, LB ;
Manieri, M ;
Donovan, MX ;
Wu, ZD ;
Cooper, MP ;
Fan, MC ;
Rohas, LM ;
Zavacki, AM ;
Cinti, S ;
Shulman, GI ;
Lowell, BB ;
Krainc, D ;
Spiegelman, BM .
CELL, 2004, 119 (01) :121-+