Platelet-activating factor receptor

被引：173

作者：

Honda, Z ^{[1
]}

Ishii, S

Shimizu, T

机构：

[1] Univ Tokyo, Fac Med, Dept Allergy, Bunkyo Ku, 7-3-1 Hongo, Tokyo 1138655, Japan

[2] Univ Tokyo, Fac Med, Dept Rheumatol, Bunkyo Ku, Tokyo 1138655, Japan

[3] Univ Tokyo, Fac Med, Dept Biochem & Mol Biol, Bunkyo Ku, Tokyo 1138655, Japan

[4] JST, CREST, Tokyo, Japan

来源：

JOURNAL OF BIOCHEMISTRY | 2002年 / 131卷 / 06期

关键词：

bronchial asthma; endotoxin shock; G protein-coupled receptors; oxidized phospholipids; platelet-activating factor;

D O I：

10.1093/oxfordjournals.jbchem.a003164

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Platelet-activating factor (PAF) is a pro-inflammatory lipid mediator possessing a unique 1-O-alkyl glycerophospholipid (GPC) backbone (1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholin). Cloned PAF receptor, which belongs to the G protein-coupled receptor superfamily, transduces pleiotropic functions including cell motility, smooth muscle contraction, and synthesis and release of mediators and cytokines via multiple heterotrimeric G proteins. Pharmacological studies have suggested that PAF functions in a variety of settings including allergy, inflammation, neural functions, reproduction, and atherosclerosis. Establishment of PAFR(-/-) mice confirmed that the PAF receptor is responsible for pro-inflammatory responses, but that its roles in other settings remain to be clarified.

引用

页码：773 / 779

页数：7

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