Microarray analysis of Drosophila development during metamorphosis

被引：356

作者：

White, KP ^{[1
]}

Rifkin, SA ^{[1
]}

Hurban, P ^{[1
]}

Hogness, DS ^{[1
]}

机构：

[1] Stanford Univ, Sch Med, Beckman Ctr B300, Dept Dev Biol, Stanford, CA 94305 USA

来源：

SCIENCE | 1999年 / 286卷 / 5447期

关键词：

D O I：

10.1126/science.286.5447.2179

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Metamorphosis is an integrated set of developmental processes controlled by a transcriptional hierarchy that coordinates the action of hundreds of genes. In order to identify and analyze the expression of these genes, high-density DNA microarrays containing several thousand Drosophila melanogaster gene sequences were constructed. Many differentially expressed genes can be assigned to developmental pathways known to be active during metamorphosis, whereas others can be assigned to pathways not previously associated with metamorphosis. Additionally, many genes of unknown function were identified that may be involved in the control and execution of metamorphosis. The utility of this genome-based approach is demonstrated for studying a set of complex biological processes in a multicellular organism.

引用

页码：2179 / 2184

页数：6

共 54 条

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