Structure of a fucoidan from the brown seaweed Fucus evanescens C.Ag.

被引：399

作者：

Bilan, MI ^{[1
]}

Grachev, AA ^{[1
]}

Ustuzhanina, NE ^{[1
]}

Shashkov, AS ^{[1
]}

Nifantiev, NE ^{[1
]}

Usov, AI ^{[1
]}

机构：

[1] Russian Acad Sci, ND Zelinskii Organ Chem Inst, Moscow 119991, Russia

来源：

CARBOHYDRATE RESEARCH | 2002年 / 337卷 / 08期

基金：

俄罗斯基础研究基金会;

关键词：

fucoidan; fucan NMR; disaccharide repeating unit; seaweed; brown algae; Fucus evanescens;

D O I：

10.1016/S0008-6215(02)00053-8

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 [生物化学与分子生物学]; 081704 [应用化学];

摘要：

A fucoidan consisting of L-fucose, sulfate and acetate in a molar proportion of 1:1.23:0.36 was isolated from the Pacific brown seaweed Fucus evanescens. The structures of its desulfated and de-O-acetylated derivatives were investigated by 1D and 2D (1)H and (13)C NMR spectroscopy, and the data obtained were confirmed by methylation analysis of the native and desulfated polysaccharides. The fucoidan was shown to contain a linear backbone of alternating 3- and 4-linked alpha-L-fucopyranose 2-sulfate residues:-->3)-alpha-L-Fucp (2SO(3)(=))-(1-->4)-alpha-L-Fucp(2SO(3)(=))-(1-->. Additional sulfate occupies position 4 in a part of 3-linked fucose residues, whereas a part of the remaining hydroxyl groups is randomly acetylated. (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

页码：719 / 730

页数：12

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