DNA methylation and the Epstein-Barr virus

被引：67

作者：

Ambinder, RF

Robertson, KD

Tao, Q

机构：

[1] Johns Hopkins Univ, Sch Med, Dept Oncol, Baltimore, MD 21231 USA

[2] Johns Hopkins Univ, Singapore, Singapore

来源：

SEMINARS IN CANCER BIOLOGY | 1999年 / 9卷 / 05期

关键词：

Epstein-Barr virus; Burkitt's lymphoma; Hodgkin's disease; nasopharyngeal carcinoma; EBNA; methylation;

D O I：

10.1006/scbi.1999.0137

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

EBV is a ubiquitous herpesvirus associated with a variety of lymphoid and epithelial tumors. In healthy lymphocytes and In tumors immune surveillance is evaded by suppression of a family of immunodominant viral antigens. Methylation of a viral promoter plays a crucial role in this suppression. Methylation of the viral genome in the latent statu over evolutionary time is believed to account for CPG suppression that distinguishes this virus from moss other large DNA viruses. Pharmacologiv manipulation of methylation may offer an opportunity to unmask viral antigens and expose tumors to immune surveillance.

引用

页码：369 / 375

页数：7

共 62 条

[1] HOST-CELL-PHENOTYPE-DEPENDENT CONTROL OF THE BCR2/BWR1 PROMOTER COMPLEX REGULATES THE EXPRESSION OF EPSTEIN-BARR-VIRUS NUCLEAR ANTIGENS 2-6 [J].