Homer proteins: implications for neuropsychiatric disorders

被引：132

作者：

Szumlinski, Karen K. ^{[1
]}

Kalivas, Peter W.

Worley, Paul F.

机构：

[1] Univ Calif Santa Barbara, Dept Psychol, Santa Barbara, CA 93106 USA

[2] Med Univ S Carolina, Dept Neurosci, Charleston, SC 29425 USA

[3] Johns Hopkins Univ, Sch Med, Dept Neurosci, Baltimore, MD 21205 USA

[4] Johns Hopkins Univ, Sch Med, Dept Neurol, Baltimore, MD 21205 USA

来源：

CURRENT OPINION IN NEUROBIOLOGY | 2006年 / 16卷 / 03期

关键词：

D O I：

10.1016/j.conb.2006.05.002

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Homer proteins regulate signal transduction, synaptogenesis and receptor trafficking, in addition to maintaining and regulating extracellular glutamate levels in limbo-corticostriatal brain regions. Converging preclinical observations indicate a potential role for both immediate early gene Homer isoforms and constitutively expressed Homer isoforms in behavioral pathologies associated with neuropsychiatric disorders, such as addiction and/or alcoholism, depression, anxiety, epilepsy and schizophrenia.

引用

页码：251 / 257

页数：7

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